Validation of the Portuguese version of the Movement Disorder Society non-motor rating scale (MDS-NMS) in Parkinson's disease

被引：0

作者：

Vale, Thiago Cardoso ^{[1
]}

Santos, Daniela Pereira ^{[1
]}

de Oliveira, Daniel Sabino ^{[1
]}

Brandao, Pedro Renato de Paula ^{[2
]}

Pereira, Danilo Assis ^{[2
]}

Bouca-Machado, Raquel ^{[3
,4
,5
]}

Silva, Leonardo Oliveira ^{[1
]}

Rieder, Carlos Roberto de Mello ^{[6
]}

Barbosa, Egberto Reis ^{[7
]}

Cury, Rubens Gisbert ^{[7
]}

Parmera, Jacy Bezerra ^{[7
]}

Teive, Helio Afonso Ghizoni ^{[8
]}

Ferreira, Matheus Gomes ^{[8
]}

Ferraz, Henrique Ballalai ^{[9
]}

da Silva, Carolina Candeias ^{[9
]}

Tumas, Vitor ^{[10
]}

Cunha, Ana Luiza Nunes ^{[10
]}

Braga-Neto, Pedro ^{[11
,12
]}

Lima, Danielle Pessoa ^{[11
]}

Della Colleta, Marcus Vinicius ^{[13
]}

Maia, Debora ^{[14
]}

Fontana, Marco de Souza ^{[14
]}

Damas, Catarina N. ^{[3
]}

Lobo, Patricia Pita ^{[3
,15
]}

Rebordao, Leonor ^{[3
]}

Magalhaes, Andreia D. ^{[3
]}

Peralta, Ana Rita ^{[3
]}

Simoes, Rita M. ^{[3
,16
]}

Lampreia, Tania ^{[16
]}

Velon, Ana Graca ^{[17
]}

Carneiro, Diogo ^{[17
]}

Raimundo, Rita ^{[17
]}

Gago, Miguel ^{[18
]}

Mendes, Alexandre ^{[19
]}

Cha, Nuno Vila ^{[19
]}

Damasio, Joana ^{[19
]}

Costa, Sara ^{[19
]}

Lopes, Rui ^{[19
]}

Morgadinho, Ana ^{[20
]}

Mestre, Tiago ^{[21
]}

Stebbins, Glenn T. ^{[22
]}

Luo, Sheng ^{[23
]}

Goetz, Christopher G. ^{[22
]}

Ferreira, Joaquim J. ^{[3
,4
,5
]}

Cardoso, Francisco ^{[14
]}

机构：

[1] Univ Fed Juiz de Fora, Juiz De Fora, MG, Brazil

[2] Inst Brasileiro Neuropsicol & Ciencias Cognit, Brasilia, DF, Brazil

[3] CNS, Campus Neurol, Torres Vedras, Portugal

[4] Univ Lisbon, Lisbon, Portugal

[5] Univ Lisbon, Fac Med, Lab Clin Pharmacol & Therapeut, Lisbon, Portugal

[6] Univ Fed Ciencias Saude Porto Alegre, Porto Alegre, Brazil

[7] Univ Fed Parana, Hosp Clin, Movement Disorders Unit, Fac Med, Sao Paulo, Brazil

[8] Univ Fed Parana, Hosp Clin, Curitiba, Parana, Brazil

[9] Univ Sao Paulo, Fac Med, Sao Paulo, Brazil

[10] Univ Fed Parana UFPR, Curitiba, Parana, Brazil

[11] Univ Fed Ceara, Hosp Univ Walter Cantidio, Fortaleza, Ceara, Brazil

[12] Univ Estadual Piaui, Hlth Sci Ctr, Fortaleza, Brazil

[13] Univ Estado Amazonas, Manaus, AM, Brazil

[14] Univ Fed Minas Gerais, Movement Disorders Unit, Belo Horizonte, Brazil

[15] ULS Santa Maria, Dept Neurosci & Mental Hlth, Neurol Dept, Ave Prof Egas Moniz, P-1649028 Lisbon, Portugal

[16] ULS Loures Odivelas, Neurol Dept, Lisbon, Portugal

[17] ULS Tras Os Montes & Alto Douro, Neurol Dept, Vila Real, Portugal

[18] ULS Alto Ave, Neurol Dept, Guimaraes, Portugal

[19] Ctr Hosp Univ Santo Antonio, ULS Santo Antonio, Neurol Dept, Porto, Portugal

[20] CEAACP Coimbra, Coimbra, Portugal

[21] Univ Ottawa, Ottawa Hosp Res Inst, Parkinsons Dis & Movement Disorders Ctr, Dept Med,Div Neurol,Brain & Mind Inst, Ottawa, ON, Canada

[22] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL USA

[23] Duke Univ, Dept Biostat & Bioinformat, Durham, NC USA

来源：

PARKINSONISM & RELATED DISORDERS | 2025年 / 132卷

关键词：

Parkinson's disease; MDS-NMS; Rating scale; Validation; Clinimetrics; ADAPTATION;

D O I：

10.1016/j.parkreldis.2025.107276

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: The Movement Disorder Society Non-Motor Rating Scale (MDS-NMS) serves as a comprehensive clinical assessment tool for non-motor symptoms in Parkinson's disease (PD) Objectives: This study aims to validate the Portuguese version of the MDS-NMS, addressing the critical need for culturally adapted rating scales in Portuguese-speaking populations. Methods: This multicenter, cross-sectional study engaged native Portuguese-speaking PD patients from 16 Movement Disorders Centers across Portugal and Brazil. We conducted a meticulous translation process into Portuguese, including forward-backward translation and cognitive pretesting. Confirmatory factor analysis (CFA) and exploratory factor analysis (EFA) were conducted to evaluate the psychometric properties and structural validity of the Portuguese version in comparison to the original English version. Tertiary analyses assessed the acceptability and reliability of domain scores within the cohort. Results: The scale was administered to 386 PD Portuguese-speaking patients. CFA, conducted with a final sample of 303 participants, confirmed that the Portuguese version maintained a factor structure consistent with the English original, with Comparative Fit Index (CFI) values meeting or exceeding the 0.90 threshold across all subscales. High CFI values in domains such as Depression, Psychosis, and Cognition underscored the robustness of the translation. EFA revealed generally strong item-factor relationships, although domains like Gastrointestinal and Non-Motor Fluctuations exhibited more complex structures. Reliability analyses demonstrated strong internal consistency, with Cronbach's alpha ranging from 0.50 to 0.86 across domains, further corroborated by McDonald's omega and Greatest Lower Bound values. Conclusions: The Portuguese version of the MDS-NMS demonstrates psychometric properties and structural validity that closely aligns with the original version.

引用

页数：7

共 50 条

[41] Quantitative assessment of non-motor fluctuations in Parkinson’s disease using the Non-Motor Symptoms Scale (NMSS)
Alexander Storch
Christine B. Schneider
Lisa Klingelhöfer
Per Odin
Gerd Fuchs
Wolfgang H. Jost
Pablo Martinez-Martin
Rainer Koch
Heinz Reichmann
K. Ray Chaudhuri
Georg Ebersbach
Journal of Neural Transmission, 2015, 122 : 1673 - 1684
[42] Quantitative assessment of non-motor fluctuations in Parkinson's disease using the Non-Motor Symptoms Scale (NMSS)
Storch, Alexander
Schneider, Christine B.
Klingelhoefer, Lisa
Odin, Per
Fuchs, Gerd
Jost, Wolfgang H.
Martinez-Martin, Pablo
Koch, Rainer
Reichmann, Heinz
Chaudhuri, K. Ray
Ebersbach, Georg
JOURNAL OF NEURAL TRANSMISSION, 2015, 122 (12) : 1673 - 1684
[43] Disease stage dependency of motor and non-motor fluctuations in Parkinson's disease
Storch, Alexander
Rosqvist, Kristina
Ebersbach, Georg
Chaudhuri, K. Ray
Fuchs, Gerd
Jost, Wolfgang H.
Odin, Per
JOURNAL OF NEURAL TRANSMISSION, 2019, 126 (07) : 841 - 851
[44] Relation of Apathy to Motor and Non-motor Findings in Parkinson's Disease
Gurbuz, Melek
Akdag, Gonul
Duz, Ozge Arici
Ozer, Feriha
Cokar, Ozlem
Hanoglu, Lutfu
HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI, 2019, 57 (02): : 129 - 134
[45] Non-motor dysfunction in Parkinson's disease
Ziemssen, Tjalf
Reichinann, Heinz
PARKINSONISM & RELATED DISORDERS, 2007, 13 (06) : 323 - 332
[46] Non-motor fluctuations in Parkinson's disease
Witjas, T.
Kaphan, E.
Azulay, J. P.
REVUE NEUROLOGIQUE, 2007, 163 (8-9) : 846 - 850
[47] Movement Disorder Society Unified Parkinson's Disease Rating Scale Motor Examination Retains Its 2-Domain Profile in Both On and Off States
Guo, Yuanyuan
Stebbins, Glenn T.
Mestre, Tiago A.
Goetz, Christopher G.
Luo, Sheng
MOVEMENT DISORDERS CLINICAL PRACTICE, 2022, 9 (08): : 1149 - 1151
[48] Non-motor symptoms in Parkinson's disease
Park, Ariane
Stacy, Mark
JOURNAL OF NEUROLOGY, 2009, 256 : S293 - S298
[49] NON-MOTOR MANIFESTSTIONS OF PARKINSON'S DISEASE
Henyk, S. I.
Hryb, V. A.
Doroshenko, O. O.
Maksymchuk, L. T.
Henyk, S. M.
Henyk, Ya. I.
WORLD OF MEDICINE AND BIOLOGY, 2019, 68 (02): : 39 - 43
[50] Non-motor symptoms of Parkinson's disease
Hou, Jyh-Gong Gabriel
Lai, Eugene C.
INTERNATIONAL JOURNAL OF GERONTOLOGY, 2007, 1 (02) : 53 - 64

← 1 2 3 4 5 →