Evaluation of clinical benefits and economic value of weight loss in a Swedish population using a simulation model

被引：0

作者：

Galavazi, Marije ^{[1
,2
]}

Wallenius, Ville ^{[3
,4
]}

Schnecke, Volker ^{[5
]}

Ericsson, Asa ^{[6
]}

Bjorklund, Helena ^{[6
]}

Jendle, Johan ^{[1
]}

机构：

[1] Orebro Univ, Fac Med & Hlth, Sch Med Sci, Orebro, Sweden

[2] Orebro Univ Hosp, Obes Unit, Orebro, Sweden

[3] Univ Gothenburg, Inst Clin Sci, Sahlgrenska Acad, Dept Surg, Gothenburg, Sweden

[4] Sahlgrens Univ Hosp, Dept Surg, Gothenburg, Sweden

[5] Novo Nord AS, Soborg, Denmark

[6] Novo Nordisk Scandinav AB, Malmo, Sweden

来源：

OBESITY | 2025年 / 33卷 / 04期

关键词：

BARIATRIC SURGERY; OVERWEIGHT; OBESITY; INTERVENTION; ASSOCIATION; OUTCOMES; DISEASE; ADULTS;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

ObjectiveThe objective of this study was to estimate the 10-year clinical benefits and economic value of weight loss in a Swedish population with obesity using a value of weight-loss simulation model.MethodsData on the prevalence of and costs associated with obesity and obesity-related complications (ORCs) were applied within an adapted simulation model to evaluate weight-loss benefits for a 2023 Swedish population over 10 years. The 10-year incidence of 10 ORCs and treatment costs in a random cohort of 10,000 individuals were estimated for a stable weight scenario and four weight-loss (5%-20%) scenarios.ResultsThe model included 887,272 individuals with obesity aged 20 to 60 years. Hypertension (24.1%), asthma (20.9%), dyslipidemia (18.3%), and type 2 diabetes (10.6%) were highly prevalent. For 10,000 individuals, a 5% to 20% weight loss was estimated to prevent ORCs over 10 years, leading to annual savings between 9.0 million Swedish krona (SEK)/<euro>0.8 million (5% weight loss) and 30.0 million SEK/<euro>2.6 million (20%) by 2033.ConclusionsAnnual treatment costs of ORCs in Sweden will double over 10 years, and weight loss would be associated with significant savings because of the reductions in the incidence of ORCs. Therefore, there is an urgent need to effectively treat obesity to prevent morbidity.

引用

页码：777 / 787

页数：11

共 49 条

[11] Pharmacotherapy of obesity: an update on the available medications and drugs under investigation [J].

Chakhtoura, Marlene ;

Haber, Rachelle ;

Ghezzawi, Malak ;

Rhayem, Caline ;

Tcheroyan, Raya ;

Mantzoros, Christos S. .

ECLINICALMEDICINE, 2023, 58

[12] The direct and indirect costs of both overweight and obesity: A systematic review [J].

Dee A. ;

Kearns K. ;

O'Neill C. ;

Sharp L. ;

Staines A. ;

O'Dwyer V. ;

Fitzgerald S. ;

Perry I.J. .

BMC Research Notes, 7 (1)

[13] 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study [J].

Bray, G. A. ;

Chatellier, A. ;

Duncan, C. ;

Greenway, F. L. ;

Levy, E. ;

Ryan, D. H. ;

Polonsky, K. S. ;

Tobian, J. ;

Ehrmann, D. ;

Matulik, M. J. ;

Clark, B. ;

Czech, K. ;

DeSandre, C. ;

Hilbrich, R. ;

McNabb, W. ;

Semenske, A. R. ;

Goldstein, B. J. ;

Smith, K. A. ;

Wildman, W. ;

Pepe, C. ;

Goldberg, R. B. ;

Calles, J. ;

Ojito, J. ;

Castillo-Florez, S. ;

Florez, H. J. ;

Giannella, A. ;

Lara, O. ;

Veciana, B. ;

Haffner, S. M. ;

Montez, M. G. ;

Lorenzo, C. ;

Martinez, A. ;

Hamman, R. F. ;

Testaverde, L. ;

Bouffard, A. ;

Dabelea, D. ;

Jenkins, T. ;

Lenz, D. ;

Perreault, L. ;

Price, D. W. ;

Steinke, S. C. ;

Horton, E. S. ;

Poirier, C. S. ;

Swift, K. ;

Caballero, E. ;

Jackson, S. D. ;

Lambert, L. ;

Lawton, K. E. ;

Ledbury, S. ;

Kahn, S. E. .

LANCET, 2009, 374 (9702) :1677-1686

[14] Long term maintenance of weight loss with non-surgical interventions in obese adults: systematic review and meta-analyses of randomised controlled trials [J].

Dombrowski, S. U. ;

Knittle, K. ;

Avenell, A. ;

Araujo-Soares, V. ;

Sniehotta, F. F. .

BMJ-BRITISH MEDICAL JOURNAL, 2014, 348

[15] 2022 American Society for Metabolic and Bariatric Surgery (ASMBS) and International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO): Indications for Metabolic and Bariatric Surgery [J].

Eisenberg, Dan ;

Shikora, Scott A. ;

Aarts, Edo ;

Aminian, Ali ;

Angrisani, Luigi ;

Cohen, Ricardo, V ;

De Luca, Maurizio ;

Faria, Silvia L. ;

Goodpaster, Kasey P. S. ;

Haddad, Ashraf ;

Himpens, Jacques M. ;

Kow, Lilian ;

Kurian, Marina ;

Loi, Ken ;

Mahawar, Kamal ;

Nimeri, Abdelrahman ;

O'Kane, Mary ;

Papasavas, Pavlos K. ;

Ponce, Jaime ;

Pratt, Janey S. A. ;

Rogers, Ann M. ;

Steele, Kimberley E. ;

Suter, Michel ;

Kothari, Shanu N. .

SURGERY FOR OBESITY AND RELATED DISEASES, 2022, 18 (12) :1345-1356

[16]

Folkhlsomyndigheten, PUBLIC HLTH AGENCY S

[17]

Folkhlsomyndigheten, WEIGHT BMI SELFREPOR

[18] Advances in the management of type 2 diabetes in adults [J].

Galindo, Rodolfo J. ;

Trujillo, Jennifer M. ;

Wang, Cecilia C. Low ;

McCoy, Rozalina G. .

BMJ MEDICINE, 2023, 2 (01)

[19] Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study [J].

Garvey, W. Timothy ;

Ryan, Donna H. ;

Look, Michelle ;

Gadde, Kishore M. ;

Allison, David B. ;

Peterson, Craig A. ;

Schwiers, Michael ;

Day, Wesley W. ;

Bowden, Charles H. .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2012, 95 (02) :297-308

[20] Physiological adaptations to weight loss and factors favouring weight regain [J].

Greenway, F. L. .

INTERNATIONAL JOURNAL OF OBESITY, 2015, 39 (08) :1188-1196

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