Nanomaterial Innovations and Machine Learning in Gas Sensing Technologies for Real-Time Health Diagnostics

被引:0
作者
Harun-Or-Rashid, Md. [1 ,2 ]
Mirzaei, Sahar [3 ]
Nasiri, Noushin [1 ,2 ]
机构
[1] Macquarie Univ, Fac Sci & Engn, Sch Engn, NanoTech Lab, Sydney, NSW 2109, Australia
[2] Macquarie Univ, Smart Green Cities Res Ctr, Sydney, NSW 2109, Australia
[3] Australia & New Zealand Banking Grp Ltd, Melbourne, Vic 3008, Australia
来源
ACS SENSORS | 2025年
关键词
breath analysis; volatile organic compounds; advanced nanomaterials; nanostructured gas sensors; machine learning; personalized health monitoring; SENSOR;
D O I
10.1021/acssensors.4c02843
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Breath sensors represent a frontier in noninvasive diagnostics, leveraging the detection of volatile organic compounds (VOCs) in exhaled breath for real-time health monitoring. This review highlights recent advancements in breath-sensing technologies, with a focus on the innovative materials driving their enhanced sensitivity and selectivity. Polymers, carbon-based materials like graphene and carbon nanotubes, and metal oxides such as ZnO and SnO2 have demonstrated significant potential in detecting biomarkers related to diseases including diabetes, liver/kidney dysfunction, asthma, and gut health. The structural and operational principles of these materials are examined, revealing how their unique properties contribute to the detection of key respiratory gases like acetone, ammonia (NH3), hydrogen sulfide, and nitric oxide. The complexity of breath samples is addressed through the integration of machine learning (ML) algorithms, including convolutional neural networks (CNNs) and support vector machines (SVMs), which optimize data interpretation and diagnostic accuracy. In addition to sensing VOCs, these devices are capable of monitoring parameters such as airflow, temperature, and humidity, essential for comprehensive breath analysis. This review also explores the expanding role of artificial intelligence (AI) in transforming wearable breath sensors into sophisticated tools for personalized health diagnostics, enabling real-time disease detection and monitoring. Together, advances in sensor materials and ML-based analytics present a promising platform for the future of individualized, noninvasive healthcare.
引用
收藏
页码:1620 / 1640
页数:21
相关论文
共 124 条
  • [91] Tian X., Cui X., Xiao Y., Chen T., Xiao X., Wang Y., Pt/MoS<sub>2</sub>/polyaniline nanocomposite as a highly effective room temperature flexible gas sensor for ammonia detection, ACS Appl. Mater. Interfaces, 15, 7, pp. 9604-9617, (2023)
  • [92] Lin Z., Nie S., He Q., Wang X., Wang Y., Zhang B., Liu B., Yang J., Wearable and Flexible Helical Pressure Sensor for Noninvasive Respiratory Monitoring, ACS Appl. Energy Mater., 1, 10, pp. 2765-2771, (2023)
  • [93] Ye Z., Liu Y., Li Q., Recent progress in smart electronic nose technologies enabled with machine learning methods, Sensors, 21, 22, (2021)
  • [94] Kaloumenou M., Skotadis E., Lagopati N., Efstathopoulos E., Tsoukalas D., Breath analysis: a promising tool for disease diagnosis─the role of sensors, Sensors, 22, 3, (2022)
  • [95] Sakumura Y., Koyama Y., Tokutake H., Hida T., Sato K., Itoh T., Akamatsu T., Shin W., Diagnosis by volatile organic compounds in exhaled breath from lung cancer patients using support vector machine algorithm, Sensors, 17, 2, (2017)
  • [96] Boubin M., Shrestha S., Microcontroller implementation of support vector machine for detecting blood glucose levels using breath volatile organic compounds, Sensors, 19, 10, (2019)
  • [97] Shaffie A., Soliman A., Eledkawy A., Fu X.-A., Nantz M.H., Giridharan G., van Berkel V., El-Baz A., Lung cancer diagnosis system based on volatile organic compounds (VOCs) profile measured in exhaled breath, Appl. Sci., 12, 14, (2022)
  • [98] Monedeiro F., Monedeiro-Milanowski M., Ratiu I.-A., Brozek B., Ligor T., Buszewski B., Needle trap device-GC-MS for characterization of lung diseases based on breath VOC profiles, Molecules, 26, 6, (2021)
  • [99] Saeki Y., Maki N., Nemoto T., Inada K., Minami K., Tamura R., Imamura G., Cho-Isoda Y., Kitazawa S., Kojima H., Lung cancer detection in perioperative patients’ exhaled breath with nanomechanical sensor array, Lung Cancer, 190, (2024)
  • [100] Hu J., Hu N., Pan D., Zhu Y., Jin X., Wu S., Lu Y., Smell cancer by machine learning-assisted peptide/MXene bioelectronic array, Biosens. Bioelectron., 262, (2024)