Multimodality Therapy and Survival Outcomes in Resectable Primary Small Cell Carcinoma of the Esophagus: A Multicenter Retrospective Study

被引：0

作者：

Xu, Lei ^{[1
]}

Yang, Yu-shang ^{[2
]}

Li, Bin ^{[3
]}

Cao, Yu-qin ^{[4
]}

Lin, Si-yun ^{[5
]}

Yu, Yong-kui ^{[6
]}

Xie, Hou-nai ^{[7
]}

Li, Hao-miao ^{[6
]}

Yuan, Yong ^{[2
]}

Chen, Xian-Kai ^{[1
]}

Li, Yong ^{[1
]}

Qin, Jian-jun ^{[1
]}

Zhang, Lin ^{[7
]}

Liu, Xian-ben ^{[6
]}

Tan, Li-jie ^{[5
]}

Li, He-cheng ^{[4
]}

Xiang, Jia-qing ^{[3
]}

Chen, Long-qi ^{[2
]}

Zhang, Rui-xiang ^{[1
]}

Li, Yin ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Dept Thorac Surg, Natl Canc Ctr, Natl Clin Res Ctr Canc,Canc Hosp, Beijing, Peoples R China

[2] Sichuan Univ, West China Hospiatal, Dept Thorac Surg, Chengdu, Sichuan, Peoples R China

[3] Fudan Univ, Dept Thorac Surg, Shanghai Canc Ctr, Shanghai, Peoples R China

[4] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Thorac Surg, Sch Med, Shanghai, Peoples R China

[5] Fudan Univ, Dept Thorac Surg, Zhongshan Hosp, Shanghai, Peoples R China

[6] Zhengzhou Univ, Affiliated Canc Hosp, Dept Thorac Surg, Henan Canc Hosp, Zhengzhou, Henan, Peoples R China

[7] Shandong First Med Univ, Dept Thorac Surg, Shandong Prov Hosp, Jinan, Shandong, Peoples R China

来源：

ANNALS OF SURGICAL ONCOLOGY | 2025年 / 32卷 / 02期

关键词：

Primary small cell carcinoma of the esophagus; Surgery; Adjuvant therapy; Neoadjuvant therapy; Survival; PROGNOSTIC-FACTORS; SEER DATABASE; LUNG-CANCER; CHEMORADIOTHERAPY; CHEMOTHERAPY; SURGERY;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background. Currently, optimal treatment strategy for resectable primary small cell carcinoma of the esophagus (PSmCCE) remains controversial. To address this, we conducted a multicenter study to evaluate treatment patterns and long-term survival of PSmCCE patients who underwent radical resection. Methods. This retrospective multicenter study included resected PSmCCE patients who received radical resection at seven high-volume cancer centers. Overall survival (OS) and median survival time (MST) were calculated by using a Kaplan-Meier method and the log-rank test was utilized to assess differences. Multivariable Cox analysis was performed to identify independent prognostic factors. Results. A total of 352 patients with resected PSmCCE were included. For PSmCCE with stage cT1-2N0M0, patients who received surgery plus adjuvant therapy showed better survival than those who received surgery alone (5-year OS rate: 32.8% vs. 19.2%, MST: 44.0 vs. 33.0 months, P = 0.035). Multivariable Cox survival analysis revealed an independent correlation between receiving surgery plus adjuvant therapy and improved OS (hazard ratio [HR] 0.529; 95% confidence interval [CI] 0.280-0.997; P = 0.049). For stage cT3N0M0/T1-3N1M0 PSmCCE, patients who received neoadjuvant therapy followed by surgery had superior long-term survival compared with those who received surgery combined with adjuvant therapy and those who received surgery alone (5-year OS rate: 27.2% vs. 9.5% vs. 0%, MST: 36.0 vs. 24.0 vs. 20.0 months, P = 0.014). Multivariable Cox survival analysis showed that neoadjuvant therapy was independently associated with improved OS (HR 0.384, 95% CI 0.203-0.728; HR 0.550, 95% CI 0.312-0.968; P = 0.013). Conclusions. Adjuvant therapy was associated with improved survival in stage cT1-2N0M0 PSmCCE, but this should be confirmed in prospective studies. For stage cT3N0M0/T1-3N1M0 cases, neoadjuvant therapy followed by surgery should be considered.

引用

页码：848 / 859

页数：12

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