Hawthorn Pectin Alleviates DSS-Induced Colitis in Mice by Ameliorating Intestinal Barrier Function and Modulating Gut Microbiota

被引:0
作者
Li, Tao [1 ,2 ]
Chen, Junbo [3 ]
Xu, Yuncong [3 ]
Ji, Wenhua [1 ,2 ]
Yang, Shaoqing [3 ]
Wang, Xiao [1 ,2 ]
机构
[1] Qilu Univ Technol, Shandong Acad Sci, Shandong Engn Res Ctr Innovat & Applicat Gen Techn, Shandong Anal & Test Ctr, Jinan 250014, Peoples R China
[2] Qilu Univ Technol, Shandong Acad Sci, Key Lab Nat Act Pharmaceut Constituents Res Univ S, Sch Pharmaceut Sci, Jinan 250014, Peoples R China
[3] China Agr Univ, Coll Food Sci & Nutr Engn, Key Lab Food Bioengn China Natl Light Ind, Beijing 100083, Peoples R China
关键词
hawthorn pectin; DSS-inducedcolitis; gut microbiota; fecal microbiota transplantation; intestinal barrier; FECAL MICROBIOTA; OLIGOSACCHARIDES;
D O I
暂无
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
Pectin, as a kind of soluble dietary fiber in hawthorns, exhibits a wide range of biological activities. Nevertheless, its role and mechanism in ulcerative colitis (UC) remain unclear. In this study, the effect of hawthorn pectin (HP) against dextran sulfate sodium (DSS)-induced UC in mice and its underlying mechanism were evaluated. HP dramatically alleviated the pathological symptoms related to colitis in mice, displaying an increase in body weight and colon length and inhibition in colon damage. Importantly, HP inhibited the serum levels of inflammation-related factors including tumor necrosis factor-alpha, IL-1 beta, and IL-6 as well as decreased the number of F4/80-positive macrophages in the colon. Moreover, the expression levels of ZO-1 and occludin proteins related to intestinal permeability were increased. A significant decrease in a dose-dependent manner at the gut bacterial genus level (such as Alistipes, Colidextribacter, and Blautia) was observed after HP treatment. HP improved the metabolic pathways of gut microbiota and increased the concentrations of short-chain fatty acids in cecal contents of UC mice. Intriguingly, fecal microbiota transplantation intervention with an HP-derived microbiome notably increased the length and relieved histopathological changes of colon in UC mice. Conclusively, our study provided valuable insights into the potential of HP as a prebiotic for maintaining intestinal health and confirmed that HP could ameliorate UC in a gut microbiota-dependent manner.
引用
收藏
页码:5872 / 5885
页数:14
相关论文
共 52 条
[11]   GM-CSF in inflammation and autoimmunity [J].
Hamilton, JA .
TRENDS IN IMMUNOLOGY, 2002, 23 (08) :403-408
[12]   Ameliorative effect of an acidic polysaccharide from Phellinus linteus on ulcerative colitis in a DSS-induced mouse model [J].
Hu, Jutuan ;
Mei, Yuxia ;
Zhang, Heng ;
Li, Ji ;
Zhang, Min ;
Li, Yanbin ;
Yang, Wendi ;
Liu, Yangyang ;
Liang, Yunxiang .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 265
[13]   Distinct protective effects of a novel Akkermansia sp. BCRC 18949 against DSS-Induced colitis in mice [J].
Huang, Chien-Hsun ;
Huang, Chih-Ting ;
Tsai, Hsu-Yun ;
Liao, Yi-Chu ;
Lin, Chiao-Mei ;
Chen, Pei-Chen ;
Liou, Jong-Shian ;
Hsu, Chin-Lin ;
Chiu, Shih-Hau ;
Chen, Chien -Chi ;
Hsieh, Sung-Yuan ;
Zou, Hsin-Bai ;
Hsu, Cheng-Chih ;
Chen, Pai-Sheng ;
Kao, Cheng-Yuan ;
Ruan, Jhen-Wei .
JOURNAL OF FUNCTIONAL FOODS, 2024, 115
[14]   Functional fractions of Astragalus polysaccharides as a potential prebiotic to alleviate ulcerative colitis [J].
Huo, Zeqi ;
Li, Junxiang ;
Li, Xiaofeng ;
Xiao, Han ;
Lin, Yang ;
Ma, Yuchan ;
Li, Jiaru ;
Yang, Hui ;
Zhang, Chunjiang .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 271
[15]   A Polysaccharide Isolated from Dictyophora indusiata Promotes Recovery from Antibiotic-Driven Intestinal Dysbiosis and Improves Gut Epithelial Barrier Function in a Mouse Model [J].
Kanwal, Sadia ;
Joseph, Thomson Patrick ;
Owusu, Lawrence ;
Ren Xiaomeng ;
Li Meiqi ;
Xin Yi .
NUTRIENTS, 2018, 10 (08)
[16]   Ulcerative colitis [J].
Kobayashi, Taku ;
Siegmund, Britta ;
Le Berre, Catherine ;
Wei, Shu Chen ;
Ferrante, Marc ;
Shen, Bo ;
Bernstein, Charles N. ;
Danese, Silvio ;
Peyrin-Biroulet, Laurent ;
Hibi, Toshifumi .
NATURE REVIEWS DISEASE PRIMERS, 2020, 6 (01)
[17]   Ulcerative colitis [J].
Le Berre, Catherine ;
Honap, Sailish ;
Peyrin-Biroulet, Laurent .
LANCET, 2023, 402 (10401) :571-584
[18]   Chaenomeles sinensis polysaccharide and its carboxymethylated derivative alleviate dextran sulfate sodium-induced ulcerative colitis via suppression of inflammation and oxidative stress [J].
Li, Chong ;
Jiao, Yukun ;
Shen, Shumin ;
Zhao, Wenchang ;
Zhang, Qian ;
Zhang, Shaojie .
BIOMEDICINE & PHARMACOTHERAPY, 2023, 169
[19]   Orally Administrated Olsalazine-Loaded Multilayer Pectin/Chitosan/ Alginate Composite Microspheres for Ulcerative Colitis Treatment [J].
Li, Jiaying ;
Pu, Yuji ;
Li, Sai ;
He, Bin ;
Chen, Jianlin .
BIOMACROMOLECULES, 2023, 24 (05) :2250-2263
[20]   Dendrobium officinale leaf polysaccharide has a dual effect of alleviating the syndromes of immunosuppressed mice and modulating immune system of normal mice [J].
Li, Jingrui ;
Tao, Wenyang ;
Zhou, Wanyi ;
Xing, Jianrong ;
Luo, Mengfan ;
Lu, Shengmin ;
Yang, Ying .
JOURNAL OF FUNCTIONAL FOODS, 2024, 113