Iron overload is closely associated with metabolic dysfunction-associated fatty liver disease in type 2 diabetes

被引:0
作者
Qu, Huanjia [1 ]
Zhou, Lingling [1 ]
Wang, Jing [1 ]
Tang, Dong [2 ]
Zhang, Qiuling [1 ]
Shi, Junping [3 ]
机构
[1] Hangzhou Normal Univ, Affiliated Hosp, Dept Endocrinol, Hangzhou, Peoples R China
[2] Hangzhou Normal Univ, Affiliated Hosp, Dept Radiol, Hangzhou, Peoples R China
[3] Hangzhou Normal Univ, Affiliated Hosp, Dept Metab Dis Ctr, Hangzhou 310015, Peoples R China
关键词
HEPATIC IRON; HOMEOSTASIS; PROGRESSION;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: The relationship between iron metabolism disturbances and metabolic dysfunction-associated fatty liver disease (MAFLD) remains controversial. This study aimed to investigate the association of iron overload with MAFLD in patients with type 2 diabetes mellitus (T2DM). Methods: This study included 155 Chinese inpatients with T2DM. MAFLD was diagnosed and grouped using magnetic resonance imaging (MRI). MRI biomarkers such as proton density fat fraction and iron accumulation (R-2*) were measured. Their clinical characteristics were compared, and the association of iron metabolism markers with MAFLD in patients with T2DM was analyzed. Results: Iron metabolism markers, including MRI-R-2*, ferritin, serum iron, hepcidin, and total iron-binding capacity, were overloaded in groups with MAFLD (p < 0.001 for trend). They were positively correlated with MAFLD and reflected the severity of MAFLD. The five markers of logistic regression analysis revealed an increased MAFLD risk (p < 0.001 for trend). The areas under the curve of five markers all exceeded 0.5, indicating certain predictive values for MAFLD. Conclusions: MAFLD is associated with significant iron overload in Chinese patients with T2DM. Serum iron, ferritin, total iron-binding capacity, hepcidin, and R-2* value are essential iron metabolism markers to evaluate and predict the progression of MAFLD in patients with T2DM.
引用
收藏
页码:490 / 499
页数:10
相关论文
共 45 条
[1]   Interactions between hepatic iron and lipid metabolism with possible relevance to steatohepatitis [J].
Ahmed, Umbreen ;
Latham, Patricia S. ;
Oates, Phillip S. .
WORLD JOURNAL OF GASTROENTEROLOGY, 2012, 18 (34) :4651-4658
[2]   Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload [J].
Altamura, Sandro ;
Muedder, Katja ;
Schlotterer, Andrea ;
Fleming, Thomas ;
Heidenreich, Elena ;
Qiu, Ruiyue ;
Hammes, Hans-Peter ;
Nawroth, Peter ;
Muckenthaler, Martina U. .
MOLECULAR METABOLISM, 2021, 51
[3]   Uncoupled iron homeostasis in type 2 diabetes mellitus [J].
Altamura, Sandro ;
Kopf, Stefan ;
Schmidt, Julia ;
Muedder, Katja ;
da Silva, Ana Rita ;
Nawroth, Peter ;
Muckenthaler, Martina U. .
JOURNAL OF MOLECULAR MEDICINE-JMM, 2017, 95 (12) :1387-1398
[4]   The role of Kupffer cells in hepatic iron and lipid metabolism [J].
不详 .
JOURNAL OF HEPATOLOGY, 2018, 69 (05) :1197-1199
[5]   Natural history of NASH [J].
Armandi, Angelo ;
Bugianesi, Elisabetta .
LIVER INTERNATIONAL, 2021, 41 :78-82
[6]  
BACON B R, 1986, Journal of Free Radicals in Biology and Medicine, V2, P339, DOI 10.1016/S0748-5514(86)80034-4
[7]   Hepcidin and iron-related gene expression in subjects with Dysmetabolic Hepatic Iron Overload [J].
Barisani, Donatella ;
Pelucchi, Sara ;
Mariani, Raffaella ;
Galimberti, Stefania ;
Trombini, Paola ;
Fumagalli, Daniela ;
Meneveri, Raffaella ;
Nemeth, Elizabeta ;
Ganz, Tomas ;
Piperno, Alberto .
JOURNAL OF HEPATOLOGY, 2008, 49 (01) :123-133
[8]   A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis [J].
Bell, Steven ;
Rigas, Andreas S. ;
Magnusson, Magnus K. ;
Ferkingstad, Egil ;
Allara, Elias ;
Bjornsdottir, Gyda ;
Ramond, Anna ;
Sorensen, Erik ;
Halldorsson, Gisli H. ;
Paul, Dirk S. ;
Eggertsson, Hannes P. ;
Burgdorf, Kristoffer S. ;
Howson, Joanna M. M. ;
Thorner, Lise W. ;
Kristmundsdottir, Snaedis ;
Astle, William J. ;
Erikstrup, Christian ;
Sigurdsson, Jon K. ;
Vuckovic, Dragana ;
Dinh, Khoa M. ;
Tragante, Vinicius ;
Surendran, Praveen ;
Pedersen, Ole B. ;
Vidarsson, Brynjar ;
Jiang, Tao ;
Paarup, Helene M. ;
Onundarson, Pall T. ;
Akbari, Parsa ;
Nielsen, Kaspar R. ;
Lund, Sigrun H. ;
Juliusson, Kristinn ;
Magnusson, Magnus, I ;
Frigge, Michael L. ;
Oddsson, Asmundur ;
Olafsson, Isleifur ;
Kaptoge, Stephen ;
Hjalgrim, Henrik ;
Runarsson, Gudmundur ;
Wood, Angela M. ;
Jonsdottir, Ingileif ;
Hansen, Thomas F. ;
Sigurdardottir, Olof ;
Stefansson, Hreinn ;
Rye, David ;
Peters, James E. ;
Westergaard, David ;
Holm, Hilma ;
Soranzo, Nicole ;
Banasik, Karina ;
Thorleifsson, Gudmar .
COMMUNICATIONS BIOLOGY, 2021, 4 (01)
[9]   EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis-2021 update [J].
Berzigotti, Annalisa ;
Tsochatzis, Emmanouil ;
Boursier, Jerome ;
Castera, Laurent ;
Cazzagon, Nora ;
Friedrich-Rust, Mireen ;
Petta, Salvatore ;
Thiele, Maja .
JOURNAL OF HEPATOLOGY, 2021, 75 (03) :659-689
[10]   Iron and non-alcoholic fatty liver disease [J].
Britton, Laurence J. ;
Subramaniam, V. Nathan ;
Crawford, Darrell H. G. .
WORLD JOURNAL OF GASTROENTEROLOGY, 2016, 22 (36) :8112-8122