Immunosenescence and age-related immune cells: causes of age-related diseases

被引：0

作者：

Kim, Nam-Hee ^{[1
]}

Sim, So-Jin ^{[1
]}

Han, Hong-Gyu ^{[1
]}

Yoon, Jeong-Hyuk ^{[1
]}

Han, Yong-Hyun ^{[1
,2
]}

机构：

[1] Kangwon Natl Univ, Coll Pharm, Lab Pathol & Physiol, Chuncheon Si 24341, Gangwon Do, South Korea

[2] Kangwon Natl Univ, Multidiment Genom Res Ctr, Chunchon 24341, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2025年 / 48卷 / 02期

关键词：

Immunosenescence; Age-related diseases; Aging; Immune cell; REGULATORY T-CELLS; REPLICATIVE SENESCENCE; CELLULAR SENESCENCE; B-CELLS; MACROPHAGES; EXPRESSION; LYMPHOCYTES; SUBSETS; MICE; EXPANSION;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Immunosenescence is a weakening of the immune system due to aging, characterized by changes in immune cells and dysregulated immune function. Age-related immune cells are increasing with aging. They are associated with chronic prolonged inflammation, causing tissue dysfunction and age-related diseases. Here, we discuss increased pro-inflammatory activity of aged macrophages, accumulation of lymphocytes with an age-associated phenotype, and specific alterations in both functions and characteristics of these immune cells. These cellular changes are associated with development of age-related diseases. Additionally, we reviewed various therapeutic strategies targeting age-related immunosenescence, providing pathways to mitigate effects of age-related diseases.

引用

页码：132 / 149

页数：18

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