Deep learning-enhanced zero echo time MRI for glenohumeral assessment in shoulder instability: a comparative study with CT

PurposeTo evaluate image quality and lesion conspicuity of zero echo time (ZTE) MRI reconstructed with deep learning (DL)-based algorithm versus conventional reconstruction and to assess DL ZTE performance against CT for bone loss measurements in shoulder instability.MethodsForty-four patients (9 females; 33.5 +/- 15.65 years) with symptomatic anterior glenohumeral instability and no previous shoulder surgery underwent ZTE MRI and CT on the same day. ZTE images were reconstructed with conventional and DL methods and post-processed for CT-like contrast. Two musculoskeletal radiologists, blinded to the reconstruction method, independently evaluated 20 randomized MR ZTE datasets with and without DL-enhancement for perceived signal-to-noise ratio, resolution, and lesion conspicuity at humerus and glenoid using a 4-point Likert scale. Inter-reader reliability was assessed using weighted Cohen's kappa (K). An ordinal logistic regression model analyzed Likert scores, with the reconstruction method (DL-enhanced vs. conventional) as the predictor. Glenoid track (GT) and Hill-Sachs interval (HSI) measurements were performed by another radiologist on both DL ZTE and CT datasets. Intermodal agreement was assessed through intraclass correlation coefficients (ICCs) and Bland-Altman analysis.ResultsDL ZTE MR bone images scored higher than conventional ZTE across all items, with significantly improved perceived resolution (odds ratio (OR) = 7.67, p = 0.01) and glenoid lesion conspicuity (OR = 25.12, p = 0.01), with substantial inter-rater agreement (K = 0.61 (0.38-0.83) to 0.77 (0.58-0.95)). Inter-modality assessment showed almost perfect agreement between DL ZTE MR and CT for all bone measurements (overall ICC = 0.99 (0.97-0.99)), with mean differences of 0.08 (- 0.80 to 0.96) mm for GT and - 0.07 (- 1.24 to 1.10) mm for HSI.ConclusionDL-based reconstruction enhances ZTE MRI quality for glenohumeral assessment, offering osseous evaluation and quantification equivalent to gold-standard CT, potentially simplifying preoperative workflow, and reducing CT radiation exposure.