Assessment of Lymphatic Drainage Through Sentinel Lymph Node Biopsy in Cutaneous Melanoma Using a Radioactive Tracer - Technetium-99m (99mTc)

被引:0
作者
Andrei, Razvan Ioan [1 ,2 ]
Voinea, Silviu Cristian [1 ,2 ]
Noditi, Aniela [1 ,2 ]
Peleasa, Teodora-Mihaela [1 ,2 ]
Gherghe, Mirela [1 ,3 ]
Blidaru, Alexandru [1 ,2 ]
机构
[1] Carol Davila Univ Med & Pharm, Bucharest, Romania
[2] Prof Dr AI Trestioreanu Inst Oncol, Dept Surg Oncol, Sos Funden 252, Bucharest 022328, Romania
[3] Prof Dr AI Trestioreanu Inst Oncol, Dept Clin Nucl Med, Bucharest, Romania
关键词
cutaneous melanoma; sentinel lymph node biopsy; radioactive tracer; multiple lymphatic drainage; LYMPHOSCINTIGRAPHY; METASTASIS; CANCER;
D O I
暂无
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background: cutaneous melanoma has often unpredictable lymphatic drainage patterns, especially at the level of the trunk, head and neck regions. Sentinel lymph node biopsy (SLNB) is an important prognostic tool that accurately assesses regional lymph node involvement and guides therapeutic decisions. Material and Methods: this prospective study involved 104 patients diagnosed with cutaneous melanoma who underwent SLNB using a radioactive tracer. Sentinel lymph nodes (SLN) were identified via lymphoscintigraphy and gamma camera guidance, followed by histopathological and immunohistochemical evaluation. Results: the SLNB identification rate was 100%. Multiple lymphatic drainage basins (LDB) were identified in 27% of cases, predominantly in trunk, head, and neck regions. The mean number of SLN identified was 2.11 by lymphoscintigraphy and 3.35 by histopathology. SLN metastases were present in 22.11% of patients. Conclusions: SLNB with a radioactive tracer is particularly useful for cutaneous melanomas of the trunk, head or neck. This technique also has less false negative results for melanomas located at the lever of the limbs.
引用
收藏
页码:666 / 675
页数:10
相关论文
共 20 条
[1]   Cutaneous melanoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up [J].
Amaral, T. ;
Ottaviano, M. ;
Arance, A. ;
Blank, C. ;
Chiarion-Sileni, V. ;
Donia, M. ;
Dummer, R. ;
Garbe, C. ;
Gershenwald, J. E. ;
Gogas, H. ;
Guckenberger, M. ;
Haanen, J. ;
Hamid, O. ;
Hauschild, A. ;
Hoeller, C. ;
Lebbe, C. ;
Lee, R. J. ;
Long, G., V ;
Lorigan, P. ;
Couselo, E. Munoz ;
Nathan, P. ;
Robert, C. ;
Romano, E. ;
Schadendorf, D. ;
Sondak, V ;
Suijkerbuijk, K. P. M. ;
van Akkooi, A. C. J. ;
Michelin, O. ;
Ascierto, P. A. .
ANNALS OF ONCOLOGY, 2025, 36 (01) :10-30
[2]   Melanoma lymphoscintigraphy and lymphatic mapping [J].
Berman, CG ;
Choi, JS ;
Hersh, MR ;
Clark, RA .
SEMINARS IN NUCLEAR MEDICINE, 2000, 30 (01) :49-55
[3]  
CABANAS RM, 1977, CANCER-AM CANCER SOC, V39, P456, DOI 10.1002/1097-0142(197702)39:2<456::AID-CNCR2820390214>3.0.CO
[4]  
2-I
[5]   False-negative sentinel lymph node biopsy for melanoma: a single-surgeon experience [J].
Downey, Julia ;
Devries, Kimberly ;
Lano, Ian Marie ;
Baliski, Christopher .
CANADIAN JOURNAL OF SURGERY, 2024, 67 (05) :E337-E344
[6]  
Dujmovic A, 2020, ACTA DERMATOVENER CR, V28, P47
[7]   Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma [J].
Faries, M. B. ;
Thompson, J. F. ;
Cochran, A. J. ;
Andtbacka, R. H. ;
Mozzillo, N. ;
Zager, J. S. ;
Jahkola, T. ;
Bowles, T. L. ;
Testori, A. ;
Beitsch, P. D. ;
Hoekstra, H. J. ;
Moncrieff, M. ;
Ingvar, C. ;
Wouters, M. W. J. M. ;
Sabel, M. S. ;
Levine, E. A. ;
Agnese, D. ;
Henderson, M. ;
Dummer, R. ;
Rossi, C. R. ;
Neves, R. I. ;
Trocha, S. D. ;
Wright, F. ;
Byrd, D. R. ;
Matter, M. ;
Hsueh, E. ;
MacKenzie-Ross, A. ;
Johnson, D. B. ;
Terheyden, P. ;
Berger, A. C. ;
Huston, T. L. ;
Wayne, J. D. ;
Smithers, B. M. ;
Neuman, H. B. ;
Schneebaum, S. ;
Gershenwald, J. E. ;
Ariyan, C. E. ;
Desai, D. C. ;
Jacobs, L. ;
McMasters, K. M. ;
Gesierich, A. ;
Hersey, P. ;
Bines, S. D. ;
Kane, J. M. ;
Barth, R. J. ;
McKinnon, G. ;
Farma, J. M. ;
Schultz, E. ;
Vidal-Sicart, S. ;
Hoefer, R. A. .
NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (23) :2211-2222
[8]  
Ferlay J EM., 2024, Global Cancer Observatory: Cancer Today (version 1.1)
[9]   Sentinel Lymph Node Mapping in Melanoma The Issue of False-Negative Findings [J].
Manca, Gianpiero ;
Rubello, Domenico ;
Romanini, Antonella ;
Boni, Giuseppe ;
Chiacchio, Serena ;
Tredici, Manuel ;
Mazzarri, Sara ;
Duce, Valerio ;
Colletti, Patrick M. ;
Volterrani, Duccio ;
Mariani, Giuliano .
CLINICAL NUCLEAR MEDICINE, 2014, 39 (07) :E346-E354
[10]   Complications following completion lymphadenectomy versus therapeutic lymphadenectomy for melanoma - A systematic review of the literature [J].
Moody, J. A. ;
Botham, S. J. ;
Dahill, K. E. ;
Wallace, D. L. ;
Hardwicke, J. T. .
EJSO, 2017, 43 (09) :1760-1767