Optogenetics and Its Application in Nervous System Diseases

被引：1
作者：
Mei, Guocheng [1 ,2 ,3 ]
Pan, Huiqiong [1 ,2 ,4 ,5 ,6 ]
Xu, Hang [3 ]
Chen, Kepei [1 ,2 ,4 ,5 ,6 ]
Zheng, Weihong [1 ,2 ,4 ,5 ,6 ]
Xu, Hualin [7 ]
Chen, Yuetong [3 ]
Lin, Wei [1 ,2 ,4 ,5 ,6 ]
Yang, Jie [8 ]
Lin, Zhenlang [1 ,2 ,4 ,5 ,6 ]
Liu, Zhiming [9 ]
Zhang, Min [1 ,2 ,4 ,5 ,6 ]
机构：
[1] Wenzhou Med Univ, Affiliated Hosp 2, Sch Med 2, Dept Pediat, 109 Xueyuan West Rd, Wenzhou 325027, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Yuying Childrens Hosp, 109 Xueyuan West Rd, Wenzhou 325027, Zhejiang, Peoples R China
[3] Wenzhou Med Univ, Sch Med 1, Wenzhou, Zhejiang, Peoples R China
[4] Key Lab Perinatal Med Wenzhou, 109 Xueyuan West Rd, Wenzhou 325027, Zhejiang, Peoples R China
[5] Key Lab Struct Malformat Children Zhejiang Prov, 109 Xueyuan West Rd, Wenzhou 325027, Zhejiang, Peoples R China
[6] Zhejiang Prov Clin Res Ctr Pediat Dis, 109 Xueyuan West Rd, Wenzhou 325027, Zhejiang, Peoples R China
[7] Zhengzhou Univ, Zhengzhou Cent Hosp, Dept Plast Surg, Zhengzhou, Henan, Peoples R China
[8] Zhejiang Univ, Affiliated Jinhua Hosp, Dept Clin Lab, Sch Med, Jinhua, Peoples R China
[9] Qingdao Univ, Affiliated Hosp, Dept Spinal Surg, 59 Haier Rd, Qingdao 266000, Shandong, Peoples R China
来源：
ADVANCED BIOLOGY | 2025年 / 9卷 / 03期
基金：
中国国家自然科学基金;
关键词：
nervous system disease; optogenetics; photosensitive protein; ADENOASSOCIATED VIRUS; MOTOR CORTEX; GENE-THERAPY; STIMULATION; BACTERIORHODOPSIN; IMPAIRMENTS; INHIBITION; STRATEGIES; TIMESCALE; RELEASE;
D O I：
10.1002/adbi.202400416
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Optogenetics is an emerging technology that uses the light-responsive effects of photosensitive proteins to regulate the function of specific cells. This technique combines genetics with optics, allowing for the precise inhibition or activation of cell functions through the introduction of photosensitive proteins into target cells and subsequent light stimulation to activate these proteins. In recent years, numerous basic and clinical studies have demonstrated the unique advantages of this approach in the research and treatment of neurological disorders. This review aims to introduce the fundamental principles and techniques of optogenetics, as well as its applications in the research and treatment of neurological diseases.
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页数：10
相关论文
共 83 条
[1]  
Oesterhelt D., Stoeckenius W., Proc. Natl. Acad. Sci. U.S.A., 70, (1973)
[2]  
Boyden E.S., Zhang F., Bamberg E., Nagel G., Deisseroth K., Nat. Neurosci., 8, (2005)
[3]  
Menken M., Munsat T.L., Toole J.F., Arch Neurol, 57, (2000)
[4]  
Vann K.T., Xiong Z.G., Int J Physiol Pathophysiol Pharmacol, 8, (2016)
[5]  
Wahl A.S., Buchler U., Brandli A., Brattoli B., Musall S., Kasper H., Ineichen B.V., Helmchen F., Ommer B., Schwab M.E., Nat. Commun., 8, (2017)
[6]  
Zhang K., Cui B., Trends. Biotechnol., 33, (2015)
[7]  
Zhang F., Vierock J., Yizhar O., Fenno L.E., Tsunoda S., Kianianmomeni A., Prigge M., Berndt A., Cushman J., Polle J., Magnuson J., Hegemann P., Deisseroth K., Cell, 147, (2011)
[8]  
Govorunova E.G., Sineshchekov O.A., Li H., Spudich J.L., Annu. Rev. Biochem., 86, (2017)
[9]  
Kim C.K., Adhikari A., Deisseroth K., Nat. Rev. Neurosci., 18, (2017)
[10]  
Yizhar O., Fenno L.E., Davidson T.J., Mogri M., Deisseroth K., Neuron, 71, (2011)
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