Clinical Characteristics of Double Seropositive Myasthenia Gravis

被引:0
作者
Lalwani, Chirag S. [1 ]
Movva, Hamsini [1 ]
Kannoth, Sudheeran [1 ,2 ]
Nambiar, Vivek [1 ]
Gopinath, Siby [1 ]
Anandakuttan, Anandkumar [1 ]
Umesh, Saraf U. [1 ]
Narayanan, Sreelakshmi [1 ]
Jose, Bijoy [1 ]
Mathai, Annamma [1 ,2 ]
Leelamani, Jyothi V. [1 ,2 ]
机构
[1] Amrita Univ, Amrita Inst Med Sci, Dept Neurol, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India
[2] Amrita Univ, Amrita Inst Med Sci, Dept Neurol, Amrita Vishwa Vidyapeetham,NeuroImmunol Lab, Kochi, Kerala, India
关键词
Acetylcholine receptor antibody; double positive myasthenia; MuSK receptor antibody; myasthenia gravis; thymoma; FREQUENCY; ANTIBODY;
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Double seropositive myasthenia gravis (DSP-MG) has antibodies positive to both acetylcholine receptor (AChR) antibody and muscle-specific tyrosine kinase (MuSK) antibody. This study aims to delineate the clinical phenotype of DSP-MG and assess the histopathological correlation with thymoma. This is a retrospective case series conducted at a tertiary care hospital in South India between February 2018 and October 2021. We had 13 DSP-MG patients (seven females, mean age 60.77+/-14.24). The presentation was generalized in nine patients, bulbar in three, and ocular in one patient. Multi-detector computed tomography done in 11 patients showed thymoma in five and thymic hyperplasia in one. Four patients underwent thymectomy; histopathology showed Type A, B2 (n = 2), and AB thymomas. All 13 patients improved with anticholinesterases. Nine patients were administered immunosuppressants, three patients were given intravenous immunoglobulin, and a single patient underwent plasmapheresis. Our study shows that DSP-MG is more similar to the clinical phenotype of AChR-MG.
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