NLRP3 inflammasomes pathway: a key target for Metformin

被引：0

作者：

Hosseini, Yasamin ^{[1
,2
]}

Niknejad, Amirhossein ^{[1
,2
]}

Sabbagh Kashani, Ayeh ^{[1
,2
]}

Gholami, Mahsa ^{[1
,2
]}

Roustaie, Mahtab ^{[1
,2
]}

Mohammadi, Mohammad ^{[3
]}

Momtaz, Saeideh ^{[4
,5
,6
]}

Atkin, Stephen L. ^{[7
]}

Jamialahmadi, Tannaz ^{[8
,9
]}

Abdolghaffari, Amir Hossein ^{[1
,2
]}

Sahebkar, Amirhossein ^{[10
,11
,12
]}

机构：

[1] Islamic Azad Univ, Fac Pharm, Dept Pharmacol & Toxicol, Tehran Med Sci, Tehran, Iran

[2] Universal Sci Educ & Res Network USERN, GI Pharmacol Interest Grp GPIG, Tehran, Iran

[3] Univ Tehran Med Sci, Sch Pharm, Tehran 1114133314, Iran

[4] ACECR, Inst Med Plants, Med Plants Res Ctr, Karaj, Iran

[5] Univ Tehran Med Sci, Inst Pharmaceut Sci TIPS, Pharmaceut Sci Res Ctr PSRC, Sch Pharm,Dept Toxicol & Pharmacol, Tehran, Iran

[6] Univ Tehran Med Sci, Inst Pharmaceut Sci TIPS, Pharmaceut Sci Res Ctr PSRC, Toxicol & Dis Grp, Tehran, Iran

[7] Royal Coll Surg Ireland, POB 15503, Adliya, Bahrain

[8] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran

[9] Mashhad Univ Med Sci, Med Toxicol Res Ctr, Mashhad, Iran

[10] Saveetha Univ, Saveetha Med Coll & Hosp, Saveetha Inst Med & Tech Sci, Ctr Global Hlth Res, Chennai, India

[11] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran

[12] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran

来源：

INFLAMMOPHARMACOLOGY | 2025年

关键词：

NLRP3; inflammasomes; Metformin; Biguanides; Inflammation; NF-KAPPA-B; ISCHEMIA-REPERFUSION INJURY; SUBCUTANEOUS ADIPOSE-TISSUE; TYPE-2; DIABETES-MELLITUS; INSULIN-RESISTANCE; SIGNALING PATHWAY; OXIDATIVE STRESS; INFLAMMATORY RESPONSE; MATRIX ACCUMULATION; MESANGIAL CELLS;

D O I：

10.1007/s10787-025-01702-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing 3 (NLRP3) is a signaling pathway that is involved in inflammatory cascades, cell survival and the immune response. NLRP3 is activated by cellular damage, oxidative stress, and other factors that stimulate the immune system. Stimulation of NLRP3 induces inflammatory reactions and the production of inflammatory cytokines. These inflammatory mediators are implicated in several diseases. Metformin (MET) is an anti-hyperglycemia agent that is extensively used in clinical practice worldwide due to its high efficiency, safety profile, and affordable price. MET is the only member of biguanide class that is used in clinical practice and a potent AMP-activated protein kinase (AMPK) agonist with proven anti-inflammatory characteristics. Due to its anti-inflammatory properties, MET is considered to be effective against diseases that have an inflammatory background, and the NLRP3 pathway is involved in the pathophysiology of these disorders. In this review, we have evaluated the evidence if MET can affect this pathway and its utility for future therapeutic approaches.

引用

页码：1729 / 1760

页数：32

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