The spine-brain axis: is spinal anatomy associated with brain volume?

被引：0

作者：

Grosu, Sergio ^{[1
]}

Nikolova, Trayana ^{[1
]}

Lorbeer, Roberto ^{[1
]}

Stoecklein, Veit M. ^{[2
]}

Rospleszcz, Susanne ^{[3
,4
]}

Fink, Nicola

Schlett, Christopher L. ^{[5
]}

Storz, Corinna ^{[6
]}

Beller, Ebba ^{[7
]}

Keeser, Daniel ^{[1
,8
]}

Heier, Margit ^{[9
]}

Kiefer, Lena S. ^{[10
,11
]}

Maurer, Elke ^{[12
]}

Walter, Sven S. ^{[13
]}

Ertl-Wagner, Birgit B. ^{[1
,14
,15
]}

Ricke, Jens ^{[1
]}

Bamberg, Fabian ^{[5
]}

Peters, Annette ^{[3
,4
,16
]}

Stoecklein, Sophia ^{[1
]}

机构：

[1] Ludwig Maximilians Univ Munchen, LMU Univ Hosp, Dept Radiol, Marchioninistr 15, D-81377 Munich, Germany

[2] Ludwig Maximilians Univ Munchen, LMU Univ Hosp, Dept Urol, D-81377 Munich, Germany

[3] Helmholtz Ctr Munich, Inst Epidemiol, German Res Ctr Environm Hlth, D-85764 Neuherberg, Germany

[4] Ludwig Maximilians Univ Munchen, Inst Med Informat Proc Biometry & Epidemiol, D-81377 Munich, Germany

[5] Univ Freiburg, Med Ctr, Fac Med, Dept Diagnost & Intervent Radiol, D-79106 Freiburg, Germany

[6] Univ Freiburg, Dept Neuroradiol, Fac Med, Dept Neurosurg, Freiburg, Germany

[7] Univ Med Ctr Rostock, Inst Diagnost & Intervent Radiol, Pediat Radiol & Neuroradiol, D-18057 Rostock, Germany

[8] Ludwig Maximilians Univ Munchen, LMU Univ Hosp, Dept Psychiat, Munich, Germany

[9] Univ Hosp Augsburg, KORA Study Ctr, D-86153 Augsburg, Germany

[10] Eberhard Karls Univ Tuebingen, Dept Diagnost & Intervent Radiol, D-72076 Tubingen, Germany

[11] Eberhard Karls Univ Tuebingen, Dept Nucl Med & Clin Mol Imaging, D-72076 Tubingen, Germany

[12] Univ Tubingen, Dept Trauma & Reconstruct Surg, BG Unfallklin Tuebingen, D-72076 Tubingen, Germany

[13] NYU, Grossman Sch Med, Dept Radiol, Div Musculoskeletal Radiol, New York, NY 10016 USA

[14] Univ Toronto, Hosp Sick Children, Dept Diagnost Imaging, Toronto, ON M5G 1E8, Canada

[15] Univ Toronto, Dept Med Imaging, Toronto, ON M5T 1W7, Canada

[16] German Ctr Diabet Res DZD, D-85764 Neuherberg, Germany

来源：

BRAIN COMMUNICATIONS | 2024年 / 6卷 / 05期

关键词：

spine; spinal canal; scoliosis; brain; magnetic resonance imaging; CEREBROSPINAL-FLUID; GLYMPHATIC SYSTEM; HYDROCEPHALUS; POPULATION; STENOSIS; DISEASE; KORA;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

First small sample studies indicate that disturbances of spinal morphology may impair craniospinal flow of cerebrospinal fluid and result in neurodegeneration. The aim of this study was to evaluate the association of cervical spinal canal width and scoliosis with grey matter, white matter, ventricular and white matter hyperintensity volumes of the brain in a large study sample. Four hundred participants underwent whole-body 3 T magnetic resonance imaging. Grey matter, white matter and ventricular volumes were quantified using a warp-based automated brain volumetric approach. Spinal canal diameters were measured manually at the cervical vertebrae 2/3 level. Scoliosis was evaluated using manual measurements of the Cobb angle. Linear binomial regression analyses of measures of brain volumes and spine anatomy were performed while adjusting for age, sex, hypertension, cholesterol levels, body mass index, smoking and alcohol consumption. Three hundred eighty-three participants were included [57% male; age: 56.3 (+/- 9.2) years]. After adjustment, smaller spinal canal width at the cervical vertebrae 2/3 level was associated with lower grey matter (P = 0.034), lower white matter (P = 0.012) and higher ventricular (P = 0.006, inverse association) volume. Participants with scoliosis had lower grey matter (P = 0.005), lower white matter (P = 0.011) and larger brain ventricular (P = 0.003) volumes than participants without scoliosis. However, these associations were attenuated after adjustment. Spinal canal width at the cervical vertebrae 2/3 level and scoliosis were not associated with white matter hyperintensity volume before and after adjustment (P > 0.864). In our study, cohort smaller spinal canal width at the cervical vertebrae 2/3 level and scoliosis were associated with lower grey and white matter volumes and larger ventricle size. These characteristics of the spine might constitute independent risk factors for neurodegeneration.

引用

页数：11

共 33 条

[1] Subclinical Disease Burden as Assessed by Whole-Body MRI in Subjects With Prediabetes, Subjects With Diabetes, and Normal Control Subjects From the General Population: The KORA-MRI Study [J].