Morphometric variation in central airways of ten different human lung

被引：0
作者：
Monfared, M. [1 ,2 ]
Mohammadzadeheydgahi, M. [1 ]
Farshidfar, Z. [3 ]
Mehrabi, S. [4 ]
Sadrizadeh, S. [5 ,6 ]
Abouali, O. [1 ,5 ]
机构：
[1] Shiraz Univ, Sch Mech Engn, Shiraz, Iran
[2] Mississippi State Univ, Dept Agr & Biol Engn, Mississippi State, MS USA
[3] Shiraz Univ Med Sci, Fac Paramed Sci, Dept Radiol, Shiraz, Iran
[4] Shiraz Univ Med Sci, Dept Internal Med, Shiraz, Iran
[5] KTH Royal Inst Technol, Stockholm, Sweden
[6] Malardalens Univ, Vasteras, Sweden
来源：
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS | 2025年 / 11卷 / 02期
关键词：
central airways; human lung model; particle deposition; 1D numerical model; AEROSOL DEPOSITION; PARTICLE DEPOSITION; COMPUTATIONAL MODEL; SEX-DIFFERENCES; FLOW; TOMOGRAPHY; TRANSPORT; PRESSURE; DELIVERY; ANGLES;
D O I：
10.1088/2057-1976/adbbf4
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The prevailing scarcity of accurate lung models poses challenges to predicting airborne particle deposition across genders. The present work demonstrates the details of the geometrical specifications of central airways for ten healthy humans (male and female). The data were extracted from HRCT scan images with a minimum resolution of 1 mm. The images cover the trachea to all branches of the G6-G8 generations. The presented data include airway segment diameters, lengths, branching angles, and angles of inclination to gravity, in addition to their average and standard deviation. Our first goal in this study is to generate an average lung model exclusively for humans in laboratory and 1D numerical inhalation investigations. Thus, our primary emphasis in this work is to find the average suitable inclination angle in all generations of central airways for men and women by comparing the available data from previous studies. In the second part of the paper, we have also investigated the particle deposition efficiency in these ten models using the Mimetikos PreludiumTM software package. We compared the regional deposition between males and females and the available respiratory system models.
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页数：24
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