Live-cell super-resolution microscopy reveals how molecules enter and exit the nucleus

被引:0
作者
Rieger, Bernd [1 ]
Berrevoets, Enya S. [1 ]
机构
[1] Delft Univ Technol, Fac Appl Sci, Dept Imaging Phys, NL-2628 CJ Delft, Netherlands
关键词
Cell biology; Biotechnology; TRANSLOCATION; TRACKING; SPEED;
D O I
10.1038/d41586-025-00804-x
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The nuclear pore complex is the gateway to the nucleus of cells. Now an in vivo imaging technique can track the way in which molecules move through this complex.
引用
收藏
页码:607 / 608
页数:2
相关论文
共 20 条
[1]  
Adam SA, 2001, GENOME BIOL, V2
[2]   Nanometer resolution imaging and tracking of fluorescent molecules with minimal photon fluxes [J].
Balzarotti, Francisco ;
Eilers, Yvan ;
Gwosch, Klaus C. ;
Gynna, Arvid H. ;
Westphal, Volker ;
Stefani, Fernando D. ;
Elf, Johan ;
Hell, Stefan W. .
SCIENCE, 2017, 355 (6325) :606-612
[3]   Super-resolved 3D tracking of cargo transport through nuclear pore complexes [J].
Chowdhury, Rajdeep ;
Sau, Abhishek ;
Musser, Siegfried M. .
NATURE CELL BIOLOGY, 2022, 24 (01) :112-+
[4]   TRANSLOCATION OF RNA-COATED GOLD PARTICLES THROUGH THE NUCLEAR-PORES OF OOCYTES [J].
DWORETZKY, SI ;
FELDHERR, CM .
JOURNAL OF CELL BIOLOGY, 1988, 106 (03) :575-584
[5]   Facilitated transport and diffusion take distinct spatial routes through the nuclear pore complex [J].
Fiserova, Jindriska ;
Richards, Shane A. ;
Wente, Susan R. ;
Goldberg, Martin W. .
JOURNAL OF CELL SCIENCE, 2010, 123 (16) :2773-2780
[6]   The Rules and Functions of Nucleocytoplasmic Shuttling Proteins [J].
Fu, Xuekun ;
Liang, Chao ;
Li, Fangfei ;
Wang, Luyao ;
Wu, Xiaoqiu ;
Lu, Aiping ;
Xiao, Guozhi ;
Zhang, Ge .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (05)
[7]   Nuclear export dynamics of RNA-protein complexes [J].
Gruenwald, David ;
Singer, Robert H. ;
Rout, Michael .
NATURE, 2011, 475 (7356) :333-341
[8]   MINFLUX nanoscopy delivers 3D multicolor nanometer resolution in cells [J].
Gwosch, Klaus C. ;
Pape, Jasmin K. ;
Balzarotti, Francisco ;
Hoess, Philipp ;
Ellenberg, Jan ;
Ries, Jonas ;
Hell, Stefan W. .
NATURE METHODS, 2020, 17 (02) :217-+
[9]   Nucleocytoplasmic transport defects in neurodegeneration - Cause or consequence? [J].
Hutten, Saskia ;
Dormann, Dorothee .
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2020, 99 :151-162
[10]   3-D particle tracking in a two-photon microscope: Application to the study of molecular dynamics in cells [J].
Levi, V ;
Ruan, QQ ;
Gratton, E .
BIOPHYSICAL JOURNAL, 2005, 88 (04) :2919-2928