Palladium-Catalyzed Asymmetric Hydrogenation of 4-Substituted 3-Alkoxycarbonylfuran-2(5H)-ones

被引：0
|
作者：
Gao, Xuan-Yu [1 ,2 ]
Wang, Han [1 ]
Jing, Huan [1 ]
Yu, Chang-Bin [1 ]
Zhou, Yong-Gui [1 ]
机构：
[1] Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
[2] Dalian Univ Technol, Sch Chem, 2 Linggong Rd, Dalian 116024, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2025年 / 90卷 / 10期
基金：
中国国家自然科学基金;
关键词：
DONOR-ACCEPTOR CYCLOPROPANES; ENANTIOSELECTIVE SYNTHESIS; KETONES; REDUCTION; DIASTEREO; LIGNANS;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Palladium-catalyzed asymmetric hydrogenation of tetrasubstituted olefin 4-substituted 3-alkoxycar-bonylfuran-2(5H)-ones was developed for the construction of 1,2-contiguous stereogenters, giving the chiral trans-4-substituted 3-alkoxycarbonylbutyrolactone derivatives with up to 95% of enantioselectivities. The asymmetric hydrogenation reaction could proceed smoothly at gram scale without any loss of reactivity and enantioselectivity. In addition, the synthetic utility of the chiral reductive products has been demonstrated through useful building blocks.
引用
收藏
页码：3752 / 3761
页数：10
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