Hymoins A–C, three unusual polycyclic polyprenylated acylphloroglucinols with lipid-lowering activity from Hypericum monogynum

被引:0
作者
Chunmao Yuan [1 ,2 ,3 ]
Yanrong Zeng [1 ,3 ,4 ]
Lei Huang [1 ,2 ,3 ]
Yu Mou [1 ,2 ,3 ]
Jun Jin [1 ,2 ,3 ]
Ping Yi [1 ,3 ]
Yanmei Li [1 ,2 ,3 ]
Xiaojiang Hao [1 ,2 ,3 ,5 ]
机构
[1] State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University
[2] School of Pharmaceutical Sciences, Guizhou Medical University
[3] Natural Products Research Center
[4] School of Chinese Ethnic Medicine, Guizhou Minzu University
[5] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of
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R965 [实验药理学]; TQ460.1 [基础理论];
学科分类号
摘要
Hymoins A–C(1–3), three unusual polycyclic polyprenylated acylphloroglucinols(PPAPs) were isolated from the flowers of Hypericum monogynum. Hymoin A features the first intriguing 6/5/5/5/7 pentacyclic caged PPAP. Hymoin B is characterized by an unprecedented rearranged 5/6/8 tricyclic ring system,while hymoin C represents the first rearranged PPAP with a fantastic spirocyclic 5/6/7 ring system. Their structures were established by extensive spectroscopic analysis, X-ray crystallography, and computational methods. The plausible biosynthetic routes for the compounds were also proposed. In oleic acid(OA)-induced HepG2 cells, all compounds exhibited significant lipid-lowering activity at the concentrations of2–8 μmol/L. Further mechanistic study implied that compound 1 exhibited excellent lipid-lowering activity in OA-induced HepG2 cells through inhibiting the proteins of free fatty acids synthesis and improving lipidolysis.
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页码:439 / 442
页数:4
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