Enantioselective and divergent construction of chiral amino alcohols and oxazolidin-2-ones via Ir-f-phamidol-catalyzed dynamic kinetic asymmetric hydrogenation

The dynamic kinetic resolution(DKR) process remains a highly efficacious approach for constructing chiral amino alcohols via the catalytic asymmetric hydrogenation of α-amino ketones. We report herein a highly efficient and enantioselective anti-selective dynamic kinetic asymmetric hydrogenation of α-amino ketones catalyzed by Ir-(S)-f-phamidol system, providing various chiral amino alcohols and chiral oxazolidin-2-ones divergently with high diastereo-and enantioselectivity(up to 99% yield, up to 99% ee and up to 99:1 dr). In addition, the reaction could be performed on the gram-scale, and the resulting chiral amino alcohols are key intermediates of norephedrine and metaraminol.