Let (X,d,μ) be a space of homogeneous type,in the sense of Coifman and Weiss,andφ:X×[0,∞)→[0,∞) satisfy that,for almost every x∈X,φ(x,·) is an Orlicz function and thatφ(·,t) is a Muckenhoupt A∞(X) weight uniformly in t∈[0,∞).In this article,the authors first establish a new molecular characterization,associated with admissible sequences of balls on X,of the Musielak-Orlicz Hardy space Hφ(X).As an application,the authors also obtain the boundedness of Calderón-Zygmund operators from Hφ(X) to Hφ(X) or to the Musielak-Orlicz space Lφ(X).The main novelty of these results is that,in the proof of the boundedness of Calderón-Zygmund operators on Hφ(X),the authors get rid of the dependence on the reverse doubling property ofμby using this new molecular characterization of Hφ(X).