Inflammation, microbiota, and pancreatic cancer

被引：1

作者：

Chen, Xiaoliang ^{[1
]}

Sun, Feixia ^{[2
]}

Wang, Xuqin ^{[3
]}

Feng, Xiaoqiang ^{[4
]}

Aref, Amir Reza ^{[5
]}

Tian, Yu ^{[6
,7
]}

Ashrafizadeh, Milad ^{[8
]}

Wu, Dengfeng ^{[9
]}

机构：

[1] Zhejiang Prov Peoples Hosp, Tiantai Peoples Hosp Zhejiang Prov, Hangzhou Med Coll, Dept Gen Surg & Integrated Tradit Chinese & Wester, Taizhou, Zhejiang, Peoples R China

[2] Shandong First Med Univ, Affiliated Occupat Dis Hosp, Shandong Prov Occupat Dis Hosp, Nursing Dept, Jinan, Peoples R China

[3] Chongqing Univ, Chongqing Gen Hosp, Dept Oncol, Chongqing 401120, Peoples R China

[4] Gaozhou Peoples Hosp, Ctr Stem Cell & Regenerat Med, Gaozhou 525200, Guangdong, Peoples R China

[5] DeepkinetiX Inc, VitroVis Dept, Boston, MA USA

[6] Guangdong Med Univ, Huizhou Cent Peoples Hosp, Res Ctr, Huizhou, Guangdong, Peoples R China

[7] Benedictine Univ, Sch Publ Hlth, 5700 Coll Rd, Lisle, IL 60532 USA

[8] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Dept Radiat Oncol, Jinan 250000, Shandong, Peoples R China

[9] Peoples Hosp Gaozhou, Dept Emergency, 89 Xiguan Rd, Gaozhou 525200, Guangdong, Peoples R China

来源：

CANCER CELL INTERNATIONAL | 2025年 / 25卷 / 01期

关键词：

Pancreatic ductal adenocarcinoma; Inflammation; Pancreatitis; Gut microbiome; Interleukins and chemokines; NF-KAPPA-B; EPITHELIAL-MESENCHYMAL TRANSITION; CHEMOKINE RECEPTOR CXCR4; HELICOBACTER-PYLORI; TUMOR MICROBIOME; INDUCED SECRETION; SIGNALING AXIS; GUT MICROBIOTA; ACINAR-CELLS; TNF-ALPHA;

D O I：

10.1186/s12935-025-03673-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic cancer (PC) is a malignancy of gastrointestinal tract threatening the life of people around the world. In spite of the advances in the treatment of PC, the overall survival of this disease in advanced stage is less than 12%. Moreover, PC cells have aggressive behaviour in proliferation and metastasis as well as capable of developing therapy resistance. Therefore, highlighting the underlying molecular mechanisms in PC pathogenesis can provide new insights for its treatment. In the present review, inflammation and related pathways as well as role of gut microbiome in the regulation of PC pathogenesis are highlighted. The various kinds of interleukins and chemokines are able to regulate angiogenesis, metastasis, proliferation, inflammation and therapy resistance in PC cells. Furthermore, a number of molecular pathways including NF-kappa B, TLRs and TGF-beta demonstrate dysregulation in PC aggravating inflammation and tumorigenesis. Therapeutic regulation of these pathways can reverse inflammation and progression of PC. Both chronic and acute pancreatitis have been shown to be risk factors in the development of PC, further highlighting the role of inflammation. Finally, the composition of gut microbiota can be a risk factor for PC development through affecting pathways such as NF-kappa B to mediate inflammation.

引用

页数：18

共 218 条

[31] Microbiome-Friend or Foe of Pancreatic Cancer? [J].