Cardiovascular comorbidities;
Cyclin-dependent kinase 4/6 inhibitor;
HR + /HER2-;
Medical claims;
Metastatic breast cancer;
QTc prolongation;
Retrospective;
Torsades de Pointes;
BREAST-CANCER;
DISEASE;
CLAIMS;
D O I:
10.1186/s40959-025-00305-w
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
BackgroundCardiovascular (CV) comorbidities and concurrent medications with risk of heart rate-corrected QT interval (QTc) prolongation can impact treatment decisions and safety discussions for patients with breast cancer. However, limited data are available regarding their prevalence in patients with HR + /HER2- metastatic breast cancer (mBC). We evaluated the prevalence of CV comorbidities, the use of concurrent medications with risk of QTc prolongation, and treatment patterns in patients with newly diagnosed HR + /HER2 - mBC.MethodsThis retrospective analysis utilized claims data from Merative (TM) Marketscan (R) Commercial and Medicare databases. Claims-based algorithms identified patients with newly diagnosed HR + /HER2- mBC between January 2016 and December 2022. The index date was defined as the first date of an mBC claim during this period. For each patient, data on pre-existing CV comorbidities and first-line treatments were captured for 12 months before and 6 months after the index date, respectively.ResultsA total of 6525 patients with newly diagnosed HR + /HER2 - mBC were identified. At mBC diagnosis, 61.7% of patients had >= 1 CV comorbidity. Of patients with CV comorbidities, 22.5% and 30.6% took 1 or >= 2 medications, respectively, with risk of QTc prolongation. First-line use of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors increased from 22.1% of patients with CV comorbidities diagnosed in 2016-2017 to 31.5% of those diagnosed in 2018-2022.ConclusionsWe found that CV comorbidities and use of medications with risk of QTc prolongation were common in patients with newly diagnosed HR + /HER2 - mBC. These factors should inform treatment decision-making (including CDK4/6 inhibitor selection), safety discussions with patients, and CV monitoring.
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[1]
[Anonymous], Merative MarketScan Research Databases 2022
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Univ N Carolina, Dept Nutr, Chapel Hill, NC USAUniv N Carolina, Dept Nutr, Chapel Hill, NC USA
Bradshaw, Patrick T.
Stevens, June
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h-index: 0
机构:
Univ N Carolina, Dept Nutr, Chapel Hill, NC USA
Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USAUniv N Carolina, Dept Nutr, Chapel Hill, NC USA
Stevens, June
Khankari, Nikhil
论文数: 0引用数: 0
h-index: 0
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Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USAUniv N Carolina, Dept Nutr, Chapel Hill, NC USA
Khankari, Nikhil
Teitelbaum, Susan L.
论文数: 0引用数: 0
h-index: 0
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Mt Sinai Sch Med, Dept Prevent Med, New York, NY USAUniv N Carolina, Dept Nutr, Chapel Hill, NC USA
Teitelbaum, Susan L.
Neugut, Alfred I.
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h-index: 0
机构:
Columbia Univ, Dept Med, New York, NY USA
Columbia Univ, Dept Epidemiol, New York, NY USAUniv N Carolina, Dept Nutr, Chapel Hill, NC USA
Neugut, Alfred I.
Gammon, Marilie D.
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h-index: 0
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Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USAUniv N Carolina, Dept Nutr, Chapel Hill, NC USA
机构:
Univ N Carolina, Dept Nutr, Chapel Hill, NC USAUniv N Carolina, Dept Nutr, Chapel Hill, NC USA
Bradshaw, Patrick T.
Stevens, June
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Nutr, Chapel Hill, NC USA
Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USAUniv N Carolina, Dept Nutr, Chapel Hill, NC USA
Stevens, June
Khankari, Nikhil
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USAUniv N Carolina, Dept Nutr, Chapel Hill, NC USA
Khankari, Nikhil
Teitelbaum, Susan L.
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Dept Prevent Med, New York, NY USAUniv N Carolina, Dept Nutr, Chapel Hill, NC USA
Teitelbaum, Susan L.
Neugut, Alfred I.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Med, New York, NY USA
Columbia Univ, Dept Epidemiol, New York, NY USAUniv N Carolina, Dept Nutr, Chapel Hill, NC USA
Neugut, Alfred I.
Gammon, Marilie D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USAUniv N Carolina, Dept Nutr, Chapel Hill, NC USA