Opportunities and challenges for patient-derived models of brain tumors in functional precision medicine

被引：1

作者：

Mann, Breanna ^{[1
,2
]}

Artz, Nichole ^{[3
]}

Darawsheh, Rami ^{[1
]}

Kram, David E. ^{[3
]}

Hingtgen, Shawn ^{[1
]}

Satterlee, Andrew B. ^{[1
,2
]}

机构：

[1] Univ North Carolina, Eshelman Sch Pharm, Div Pharmacoengineering & Mol Pharmaceut, Chapel Hill, NC 27599 USA

[2] Univ North Carolina, Eshelman Inst Innovat, Chapel Hill, NC 27599 USA

[3] Univ North Carolina, Div Pediat Hematol Oncol, Chapel Hill, NC USA

来源：

NPJ PRECISION ONCOLOGY | 2025年 / 9卷 / 01期

基金：

美国国家卫生研究院;

关键词：

GLIOMA-CELL LINES; STEM-CELLS; GLIOBLASTOMA; CANCER; ORGANOIDS; CULTURE; XENOGRAFTS; GROWTH; HETEROGENEITY; RESISTANCE;

D O I：

10.1038/s41698-025-00832-w

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Here, we review a growing paradigm shift from genomics-based precision medicine toward functional precision medicine, which evaluates therapeutic efficacy by directly treating living patient tumors ex vivo to better predict patient-specific responses to treatment. We discuss several classes of patient-derived models of central nervous system tumors, highlighting unique features of each. Each class of models holds promise to improve treatment selection, prolong survival, and enhance patient outcomes.

引用

页数：16

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