Innovative treatment of age-related hearing loss using MSCs and EVs with Apelin

被引：1
作者：
Xu, Shengqun [1 ]
Liu, Dongliang [2 ]
Zhang, Fang [3 ]
Tian, Yuan [2 ]
机构：
[1] China Med Univ, Ear Nose Throat Head & Neck Surg Comprehens Ward, Shengjing Hosp, Shenyang 110020, Peoples R China
[2] China Med Univ, Dept Otolaryngol Head & Neck Surg, Shengjing Hosp, Shenyang 110004, Peoples R China
[3] China Med Univ, Affiliated Hosp 4, Dept Otorhinolaryngol, Shenyang 110032, Peoples R China
来源：
CELL BIOLOGY AND TOXICOLOGY | 2025年 / 41卷 / 01期
关键词：
Mesenchymal stem cells; Age-related hearing loss; Single-cell transcriptome sequencing; Hair cell regeneration; Extracellular vesicles; M2 macrophage polarization; MESENCHYMAL STEM-CELLS; MACROPHAGE; INFLAMMATION; CANCER;
D O I：
10.1007/s10565-025-09988-4
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Utilizing single-cell transcriptome sequencing (scRNA-seq) technology, this study explores the viability of employing mesenchymal stem cells (MSCs) as a therapeutic approach for age-related hearing loss (ARHL). The research demonstrates MSCs' ability to differentiate into inner ear cell subpopulations, particularly hair cells, delivering Apelin via extracellular vesicles (EVs) to promote M2 macrophage polarization. In vitro experiments show reduced inflammation and preservation of hair cell health. In elderly mice, MSCs transplantation leads to hair cell regeneration, restoring auditory function. These findings highlight the regenerative capabilities of MSCs and EV-mediated therapeutic approaches for ARHL.
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页数：27
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