Role of Chemokines and Cytokines in Prostate Cancer Skeletal Metastasis

被引：0

作者：

Shiozawa, Yusuke ^{[1
,2
]}

Parajuli, Keshab Raj ^{[3
]}

Pienta, Kenneth ^{[4
,5
,6
,7
]}

Taichman, Russell ^{[3
,4
,8
,9
]}

机构：

[1] Wake Forest Univ Hlth Sci, Dept Canc Biol, Winston Salem, NC 27157 USA

[2] Wake Forest Univ Hlth Sci, Comprehens Canc Ctr, Winston Salem, NC 27157 USA

[3] Univ Alabama Birmingham, Dept Periodontol, Birmingham, AL 35294 USA

[4] Johns Hopkins Sch Med, Brady Urol Inst, Canc Ecol Ctr, 600 N Wolfe St,Marburg Bldg Room 113, Baltimore, MD 21287 USA

[5] Johns Hopkins Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD USA

[6] Johns Hopkins Sch Med, Dept Oncol, Baltimore, MD USA

[7] Johns Hopkins Whiting Sch Engn, Dept Chem & Biomol Engn, Baltimore, MD USA

[8] Univ Michigan, Sch Dent, Dept Periodont & Oral Med, Ann Arbor, MI 48104 USA

[9] Tufts Univ, Dept Basic & Clin Translat Sci, Sch Dent Med, Boston, MA 02111 USA

来源：

CURRENT OSTEOPOROSIS REPORTS | 2025年 / 23卷 / 01期

关键词：

Cytokines; Chemokines; Prostate cancer; Skeletal metastases; Disseminated tumor cells; TGF-BETA; TUMOR; GROWTH; PROLIFERATION; DIFFERENTIATION; INFLAMMATION; FIBROBLASTS; EXPRESSION; MECHANISM; SURVIVAL;

D O I：

10.1007/s11914-024-00897-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of ReviewOnce prostate cancer (PCa) bone metastases develop, the prognosis dramatically declines. The precise mechanisms regulating bone metastasis remain elusive. This review will explore recent findings related to cytokines and chemokines in the process of bone metastases.Recent FindingsWe discuss the role of cytokines in tumor growth, invasion, bone remodelling and angiogenesis and immune regulation in PCa skeletal metastases. Major advances in our understanding focus on immune evasion, immune checkpoint blockade, tumor-associated macrophages (TAMs), CAR-T cells, cytokine regulation of matrix metalloproteinases, cytokines including IL-10, IL-27, Interferon-gamma, prostate transmembrane protein androgen induced 1 (Pmepa1), and regulation of RUNX2 transcription in supporting survival and growth of disseminated tumor cells (DTCs) and metastases development.SummaryThe review highlights the complexity of cytokine actions in PCa bone metastases, suggesting potential therapeutic targets to disrupt interactions between cancer cells and their microenvironment.

引用

页数：11

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