Immune therapeutic strategies for the senescent tumor microenvironment

被引：0

作者：

Yasuda, Tadahito ^{[1
]}

Wang, Y. Alan ^{[1
,2
]}

机构：

[1] Indiana Univ Sch Med, Brown Ctr Immunotherapy, Dept Med, Indianapolis, IN 46202 USA

[2] Indiana Univ, Melvin & Bren Simon Comprehens Canc Ctr, Indianapolis, IN USA

来源：

BRITISH JOURNAL OF CANCER | 2025年 / 132卷 / 03期

关键词：

CELLULAR SENESCENCE; EMERGING TARGET; LIVER-CANCER; CELLS; CHEMOTHERAPY; CLEARANCE; AGE; P53; SURVEILLANCE; SUPPRESSION;

D O I：

10.1038/s41416-024-02865-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Senescent cells can either to promote immunosuppressive tumor microenvironment or facilitate immune surveillance. Despite the revolutionary impact of cancer immunotherapy, durable responses in solid tumors, particularly in advanced stages, remain limited. Recent studies have shed light on the influence of senescent status within the tumor microenvironment (TME) on therapy resistance and major efforts are needed to overcome these challenges. This review summarizes recent advancements in targeting cellular senescence, with a particular focus on immunomodulatory approaches on the hallmarks of cellular senescence.

引用

页码：237 / 244

页数：8

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