Association between pulse wave velocity and cerebral microbleeds: a systematic review and meta-analysis

被引:4
作者
Lever-Megina, Carla Geovanna [1 ]
Cavero-Redondo, Ivan [1 ,2 ]
Saz-Lara, Alicia [1 ]
Moreno-Herraiz, Nerea [1 ]
Rescalvo-Fernandez, Elena [1 ]
Otero-Luis, Iris [1 ]
机构
[1] Univ Castilla La Mancha, Fac Enfermeria Cuenca, CarVasCare Res Grp, Cuenca 16001, Spain
[2] Univ Autonoma Chile, Fac Ciencias Salud, Talca 3460000, Chile
基金
英国科研创新办公室;
关键词
Cerebral small vessel disease; Cerebral microbleeds; Arterial stiffness; Pulse wave velocity; Aging; Systematic review; Meta-analysis; SMALL-VESSEL DISEASE; ARTERIAL STIFFNESS; GENE/ENVIRONMENT SUSCEPTIBILITY; NEUROPSYCHIATRIC SYMPTOMS; COGNITIVE IMPAIRMENT; AORTIC STIFFNESS; ISCHEMIC-STROKE; RISK; AGE; BRAIN;
D O I
10.1038/s41440-024-01963-6
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Cerebral microbleeds are associated with events that are among the highest mortality and disability events combined worldwide, as well as with hypertensive vasculopathy. The aim of the present study was to investigate the relationship between a marker of hypertensive vasculopathy, arterial stiffness assessed by pulse wave velocity, and cerebral microbleeds. A systematic review and meta-analysis was performed using PubMed, Scopus, and Web of Science, according to the Meta-analysis of Observational Studies in Epidemiology (MOOSE) and Cochrane Collaboration Handbook statements. Data extraction, quality assessment and statistical analyses were performed following pre-established criteria. Twenty-one studies involving 18,436 participants were included. Higher levels of pulse wave velocity were associated with a higher presence of cerebral microbleeds p-OR = 1.26 (95% CI; 1.09-1.45), with considerable heterogeneity; even adjusting for potential confounding variables p-OR = 1.12 (95% CI, 1.05-1.20), with substantial heterogeneity. Only the percentage of women was related to p-OR in the adjusted model. Sensitivity analyses confirmed the robustness of our results. Adjusted models showed publication bias. Higher levels of arterial stiffness are associated with greater presence of cerebral microbleeds. This phenomenon may be caused by damage to the brain under higher blood flow loads, in turn due to age-induced reversal of the stiffness gradient between large and small vessels. As the world's population is undergoing demographic ageing, our results underline the importance of establishing pulse wave velocity as a cardiovascular marker for early screening and delaying the onset of the characteristic signs of both diseases.
引用
收藏
页码:314 / 326
页数:13
相关论文
共 78 条
[1]   Association of Cerebral Microbleeds With Cognitive Decline and Dementia [J].
Akoudad, Saloua ;
Wolters, Frank J. ;
Viswanathan, Anand ;
de Bruijn, Renee F. ;
van der Lugt, Aad ;
Hofman, Albert ;
Koudstaal, Peter J. ;
Ikram, M. Arfan ;
Vernooij, Meike W. .
JAMA NEUROLOGY, 2016, 73 (08) :934-943
[2]   Cerebral Microbleeds Are Predictive of Mortality in the Elderly [J].
Altmann-Schneider, Irmhild ;
Trompet, Stella ;
de Craen, Anton J. M. ;
van Es, Adriaan C. G. M. ;
Jukema, J. Wouter ;
Stott, David J. ;
Sattar, Naveed ;
Westendorp, Rudi G. J. ;
van Buchem, Mark A. ;
van der Grond, Jeroen .
STROKE, 2011, 42 (03) :638-644
[3]  
[Anonymous], 2014, QUALITY ASSESSMENT T
[4]   Large Vessel Disease Modifies the Relationship Between Kidney Injury and Cerebral Small Vessel Disease [J].
Ao, Dong-Hui ;
Zhai, Fei-Fei ;
Han, Fei ;
Zhou, Li-Xin ;
Ni, Jun ;
Yao, Ming ;
Zhang, Ding-Ding ;
Li, Ming-Li ;
Fan, Xiao-Hong ;
Jin, Zheng-Yu ;
Cui, Li-Ying ;
Zhang, Shu-Yang ;
Zhu, Yi-Cheng .
FRONTIERS IN NEUROLOGY, 2018, 9
[5]   EFFECTS OF AGING ON CHANGING ARTERIAL COMPLIANCE AND LEFT-VENTRICULAR LOAD IN A NORTHERN CHINESE URBAN-COMMUNITY [J].
AVOLIO, AP ;
CHEN, SG ;
WANG, RP ;
ZHANG, CL ;
LI, MF ;
OROURKE, MF .
CIRCULATION, 1983, 68 (01) :50-58
[6]   Association between arterial stiffness and the presence of cerebral small vessel disease markers [J].
Bae, Jae-Han ;
Kim, Jeong-Min ;
Park, Kwang-Yeol ;
Han, Su-Hyun .
BRAIN AND BEHAVIOR, 2021, 11 (01)
[7]   Arterial Stiffness and Cardiovascular Risk in Hypertension [J].
Boutouyrie, Pierre ;
Chowienczyk, Phil ;
Humphrey, Jay D. ;
Mitchell, Gary F. .
CIRCULATION RESEARCH, 2021, 128 (07) :864-886
[8]   Vascular function in hypertension: does gender dimension matter? [J].
Bruno, Rosa-Maria ;
Varbiro, Szabolcs ;
Pucci, Giacomo ;
Nemcsik, Janos ;
Lonnebakken, Mai Tone ;
Kublickiene, Karolina ;
Schluchter, Helena ;
Park, Chloe ;
Mozos, Ioana ;
Guala, Andrea ;
Hametner, Bernhard ;
Seeland, Ute ;
Boutouyrie, Pierre .
JOURNAL OF HUMAN HYPERTENSION, 2023, 37 (08) :634-643
[9]   Large Artery Stiffness Assessment Using SphygmoCor Technology [J].
Butlin, Mark ;
Qasem, Ahmad .
PULSE, 2016, 4 (04) :180-192
[10]   Association of Cerebral Small Vessel Disease Burden with Neuropsychiatric Symptoms in Non-Demented Elderly: A Longitudinal Study [J].
Cao, Qiao-Ling ;
Sun, Yan ;
Hu, Hao ;
Wang, Zuo-teng ;
Tan, Lan ;
Yu, Jin-Tai .
JOURNAL OF ALZHEIMERS DISEASE, 2022, 89 (02) :583-592