Independent prognostic significance of tissue and circulating microrna biomarkers in hepatocellular carcinoma

被引：0

作者：

Jeng, Long-Bin ^{[1
,2
,3
]}

Chan, Wen-Ling ^{[4
,5
]}

Teng, Chiao-Fang ^{[1
,6
,7
]}

机构：

[1] China Med Univ Hosp, Organ Transplantat Ctr, Taichung 404, Taiwan

[2] China Med Univ Hosp, Dept Surg, Taichung 404, Taiwan

[3] China Med Univ Hosp CMUH, Cell Therapy Ctr, Taichung 404, Taiwan

[4] China Med Univ, Coll Publ Hlth, Dept Publ Hlth, Taichung 404, Taiwan

[5] Asia Univ, Coll Med & Hlth Sci, Dept Healthcare Adm, Taichung 413, Taiwan

[6] China Med Univ, Grad Inst Biomed Sci, 91Hsueh-Shih Rd, Taichung 404, Taiwan

[7] China Med Univ, Master Program Canc Biol & Drug Discovery, Taichung 404, Taiwan

来源：

DISCOVER ONCOLOGY | 2025年 / 16卷 / 01期

关键词：

Hepatocellular carcinoma; MicroRNA; Tissue; Circulating; Prognostic biomarker; PREDICTS POOR-PROGNOSIS; TUMOR-METASTASIS; DOWN-REGULATION; EXPRESSION; PROLIFERATION; INVASION; MARKERS; MIGRATION; MIR-218;

D O I：

10.1007/s12672-025-02043-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. Although many therapeutic modalities have been established for treating HCC patients, the outcomes of patients remain unsatisfactory. Development of independent prognostic biomarkers is thus an important need to allow for early diagnosis and timely treatment. MicroRNAs (miRNAs) are the most studied class of small non-coding RNAs. It has been shown that miRNAs play essential roles in the multiple steps of HCC tumorigenesis and progression. Furthermore, the baseline expression levels of many miRNAs are altered in tumor tissues and blood circulation of HCC patients. Therefore, miRNAs have emerged as independent biomarkers for the prediction of HCC prognosis. This review provides a comprehensive literature-based summary of tissue and circulating miRNA biomarkers with independent prognostic significance in HCC.

引用

页数：9

共 94 条

[1]

Ali D. A., 2021, Medicina (Kaunas), V57, P9

[2] microRNAs: Tiny regulators with great potential [J].