Exploring the potential role of microtubule associated proteins-2 in the pathogenesis of HIV associated neurocognitive disorders

被引：0

作者：

Becher, Melanie K. ^{[1
,2
]}

Avdoshina, Valeria ^{[1
,2
]}

Campbell, Lee A. ^{[1
,2
]}

Mocchetti, Italo ^{[1
,2
]}

机构：

[1] Georgetown Univ, Interdisciplinary Program Neurosci, Med Ctr, WP13 New Res Bldg,3970 Reservoir Rd,NW, Washington, DC 20057 USA

[2] Georgetown Univ, Dept Neurosci, Lab Preclin Neurobiol, Med Ctr, WP13 New Res Bldg,3970 Reservoir Rd,NW, Washington, DC 20057 USA

来源：

NEUROTOXICITY RESEARCH | 2025年 / 43卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Gp120; HAND; HIVE; MAP2; Neuronal cytoskeleton; Neurotoxicity; ANTIRETROVIRAL THERAPY; MAP2; PHOSPHORYLATION; GP120; BRAIN; TAU; ENCEPHALITIS; LOCALIZATION; TRAFFICKING; TRANSPORT;

D O I：

10.1007/s12640-025-00739-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

HIV-associated neurocognitive disorder (HAND) persists in people living with HIV (PLWH) despite antiretroviral therapy. HAND is characterized by synapto-dendritic damage, yet the cause of this pathology is still under investigation. Various viral proteins, including the envelope protein gp120, have been proposed to be the leading neurotoxic agents underlying HIV-mediated neuronal degeneration. Gp120 has been shown to bind to neuronal microtubules (MTs) and impair their functions. The dynamic properties of MTs are modulated by microtubule-associated proteins (MAP), including MAP2, which is particularly abundant in dendrites. This review article explores how gp120 could be altering the function of the neuronal cytoskeleton by affecting MAP2. These effects may serve as a causal link between viral proteins and HAND pathology.

引用

页数：10

共 66 条

[1]

Alakkas A., 2018, Journal of neurovirology

[2] Recent Advances in the Molecular and Cellular Mechanisms of gp120-Mediated Neurotoxicity [J].