Fusobacterium nucleatum confirmed in gastric biopsies of patients without Helicobacter pylori

被引：0

作者：

Kamali, Negin ^{[1
]}

Abadi, Amin Talebi Bezmin ^{[1
]}

Rahimi, Farid ^{[2
]}

Forootan, Mojgan ^{[3
]}

机构：

[1] Tarbiat Modares Univ, Fac Med Sci, Dept Bacteriol, Room 107,First floor, Tehran, Iran

[2] Australian Natl Univ, Res Sch Biol, Canberra, ACT, Australia

[3] Shahid Beheshti Univ Med Sci, Res Inst Gastroenterol & Liver Dis, Gastroenterol & Liver Dis Res Ctr, Tehran, Iran

来源：

BMC RESEARCH NOTES | 2025年 / 18卷 / 01期

基金：

美国国家科学基金会;

关键词：

Biopsy; DNA; F; nucleatum; Gastric cancer; Gastroduodenal diseases; H; pylori; PCR; CANCER; CARCINOGENESIS; INFLAMMATION; MECHANISMS; MICROBIOTA; BACTERIA;

D O I：

10.1186/s13104-025-07165-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Objective Putative associations between certain bacteria and gastric cancer have been described previously; however, the mechanisms underlying such associations are not thoroughly understood. We aimed to confirm the presence of Fusobacterium nucleatum in the biopsy samples of patients with gastroduodenal diseases, including gastric cancer, with concomitant or without Helicobacter pylori infection. Results Three hundred patients with gastroduodenal disorders, including gastritis, duodenal ulcer, or gastric cancer, were included. One hundred and eighty (60%) patients were negative and 120 (40%) positive for H. pylori. Associations between the presence of H. pylori and age, gender, or other demographics were statistically insignificant (p > 0.05). The prevalence of F. nucleatum infection was determined for the two patient categories: 215 patients (72%) were positive for F. nucleatum; of these cases, 95 showed evidence of, and 120 lacked, concomitant H. pylori infection. Gastric biopsies obtained from patients with gastric cancer but negative for H. pylori revealed a significant prevalence of F. nucleatum infection.

引用

页数：6

共 38 条

[1] Colon Cancer-AssociatedFusobacterium nucleatumMay Originate From the Oral Cavity and Reach Colon Tumors via the Circulatory System [J].

Abed, Jawad ;

Maalouf, Naseem ;

Manson, Abigail L. ;

Earl, Ashlee M. ;

Parhi, Lishay ;

Emgard, Johanna E. M. ;

Klutstein, Michael ;

Tayeb, Shay ;

Almogy, Gideon ;

Atlan, Karine A. ;

Chaushu, Stella ;

Israeli, Eran ;

Mandelboim, Ofer ;

Garrett, Wendy S. ;

Bachrach, Gilad .

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2020, 10

[2] Fusobacterium nucleatum is associated with worse prognosis in Lauren's diffuse type gastric cancer patients [J].

Boehm, Ellen Teresa ;

Thon, Cosima ;

Kupcinskas, Juozas ;

Steponaitiene, Ruta ;

Skieceviciene, Jurgita ;

Canbay, Ali ;

Malfertheiner, Peter ;

Link, Alexander .

SCIENTIFIC REPORTS, 2020, 10 (01)

[3] Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects [J].

Bravo, Denisse ;

Hoare, Anilei ;

Soto, Cristopher ;

Valenzuela, Manuel A. ;

Quest, Andrew F. G. .

WORLD JOURNAL OF GASTROENTEROLOGY, 2018, 24 (28) :3071-3089

[4] Detection of the glmM Gene in Helicobacter pylori Isolates with a Novel Primer by PCR [J].

Cordova Espinoza, Maria Guadalupe ;

Gonzalez Vazquez, Rosa ;

Morales Mendez, Iyari ;

Ruelas Vargas, Consuelo ;

Giono Cerezo, Silvia .

JOURNAL OF CLINICAL MICROBIOLOGY, 2011, 49 (04) :1650-1652

[5]

de Leeuw MA, 2020, Exploratory Research and Hypothesis in Medicine, V000, P1, DOI [10.14218/erhm.2020.00024, 10.14218/ERHM.2020.00024, DOI 10.14218/ERHM.2020.00024]

[6] The role of the microbiota in inflammation, carcinogenesis, and cancer therapy [J].