AI prediction model for endovascular treatment of vertebrobasilar occlusion with atrial fibrillation

被引：2

作者：

Huang, Zhi-Xin ^{[1
,2
]}

Alexandre, Andrea M. ^{[3
]}

Pedicelli, Alessandro ^{[3
]}

He, Xuying ^{[1
]}

Hong, Quanlong ^{[4
]}

Li, Yongkun ^{[5
]}

Chen, Ping ^{[6
]}

Cai, Qiankun ^{[7
]}

Broccolini, Aldobrando ^{[8
,9
]}

Scarcia, Luca ^{[10
]}

Abruzzese, Serena ^{[9
]}

Cirelli, Carlo ^{[11
]}

Bergui, Mauro ^{[12
]}

Romi, Andrea ^{[13
]}

Kalsoum, Erwah ^{[10
]}

Frauenfelder, Giulia ^{[14
]}

Meder, Grzegorz ^{[15
]}

Scalise, Simona ^{[16
]}

Ganimede, Maria Porzia ^{[17
]}

Bellini, Luigi ^{[18
]}

Del Sette, Bruno ^{[19
]}

Arba, Francesco ^{[20
]}

Sammali, Susanna ^{[21
]}

Salcuni, Andrea ^{[22
]}

Vinci, Sergio Lucio ^{[23
]}

Cester, Giacomo ^{[24
]}

Roveri, Luisa ^{[25
]}

Huang, Xianjun ^{[26
]}

Sun, Wen ^{[27
]}

机构：

[1] Jinan Univ, Affiliated Guangdong Prov Gen Hosp 2, Affiliated Guangdong Prov Gen Hosp 2, Guangzhou, Guangdong, Peoples R China

[2] Guangzhou Univ Chinese Med, Guangzhou 510317, Guangdong, Peoples R China

[3] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Diagnost Immagini Radioterapia Oncol, UOC Radiol & Neuroradiol, I-00168 Rome, Italy

[4] Quanzhou First Hosp, Dept Neurol, Quanzhou 362000, Fujian, Peoples R China

[5] Fujian Med Univ, Shengli Clin Med Coll, Shengli Clin Med Coll, Fuzhou 350000, Fujian, Peoples R China

[6] First Hosp Putian City, Dept Pathol, Putian 351100, Fujian, Peoples R China

[7] Fujian Med Univ, Affiliated Hosp 2, Dept Neurol, Quanzhou 362000, Fujian, Peoples R China

[8] Fdn Policlin Univ A Gemelli IRCCS, Neurol Unit, I-00118 Rome, Italy

[9] INAF, I-00153 Rome, Italy

[10] Henri Mondor Hosp, Neuroradiol Unit, F-94000 Creteil, France

[11] Univ Hosp Policlin Umberto I, Dept Human Neurosci Intervent Neuroradiol, I-00118 Rome, Italy

[12] Univ Turin, Azienda Osped Citta Salute & Sci Hosp, Dept Neurosci, Neuroradiol Unit, I-10139 Turin, Italy

[13] IRCCS Policlin San Matteo, Neuroradiol Unit, I-27100 Pavia, Italy

[14] AOU S Giovanni Dio & Ruggi Aragona, Neuroradiol Unit, I-84122 Salerno, Italy

[15] Jan Biziel Univ Hosp 2, Dept Intervent Radiol, Ujejskiego 75 St, PL-85168 Bydgoszcz, Poland

[16] Osped Vito Fazzi, UOC Neurol Stroke Unit, I-73100 Lecce, Italy

[17] SS Annunziata Hosp, Intervent Radiol Unit, I-74121 Taranto, Italy

[18] Univ Hosp Rome Tor Vergata, Dept Biomed & Prevent, I-00118 Rome, Italy

[19] IRCCS Osped Policlin San Martino, Neuroradiol Unit, I-16158 Genoa, Italy

[20] AOU Careggi Univ Hosp, Stroke Unit, I-01062 Florence, Italy

[21] Univ Florence, NEUROFARBA Dept, I-01062 Florence, Italy

[22] Sapienza Univ Rome, Dept Radiol Sci Oncol & Pathol, I-00118 Rome, Italy

[23] AOU Policlin G Martino, Neuroradiol Unit, Biomed Sci & Morphol & Funct Images, I-98100 Messina, Italy

[24] Univ Padua Polyclin, Neuroradiol Unit, I-35100 Padua, Italy

[25] IRCCS San Raffaele Univ Hosp, Neurol Unit, Stroke Unit, I-20121 Milan, Italy

[26] Wannan Med Coll, Yijishan Hosp, Dept Neurol, Wuhu 241000, Anhui, Peoples R China

[27] Univ Sci & Technol China, Affiliated Hosp 1, Ctr Leading Med & Adv Technol IHM, Dept Neurol,Div Life Sci & Med, Hefei 230000, Anhui, Peoples R China

来源：

NPJ DIGITAL MEDICINE | 2025年 / 8卷 / 01期

关键词：

HEMORRHAGIC TRANSFORMATION; ARTERY-OCCLUSION; STROKE; THROMBOLYSIS; THROMBECTOMY; THERAPY; TRIAL;

D O I：

10.1038/s41746-025-01478-5

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Endovascular treatment (EVT) for vertebrobasilar artery occlusion (VBAO) with atrial fibrillation presents complex clinical challenges. This comprehensive multicenter study of 525 patients across 15 Chinese provinces investigated nuanced predictors beyond conventional metrics. While 45.1% achieved favorable outcomes at 90 days, our advanced machine learning approach unveiled subtle interaction effects among clinical variables not captured by traditional statistical methods. The predictive model distinguished high-risk subgroups by integrating multiple parameters, demonstrating superior prognostic precision compared to standard NIHSS-based assessments. Novel findings include nonlinear relationships between dyslipidemia, stroke severity, and functional recovery. The developed predictive algorithm (AUC 0.719 internally, 0.684 externally) offers a more sophisticated risk stratification tool, potentially guiding personalized treatment strategies in high-complexity VBAO patients with atrial fibrillation.

引用

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