Association between choroid plexus volume and cognitive function in community-dwelling older adults without dementia: a population-based cross-sectional analysis

被引：1

作者：

Yosuke Hidaka ^{[1
]}

Mamoru Hashimoto ^{[2
]}

Takashi Suehiro ^{[1
]}

Ryuji Fukuhara ^{[3
]}

Tomohisa Ishikawa ^{[4
]}

Naoko Tsunoda ^{[5
]}

Asuka Koyama ^{[5
]}

Kazuki Honda ^{[6
]}

Yusuke Miyagawa ^{[7
]}

Kazuhiro Yoshiura ^{[6
]}

Seiji Yuuki ^{[8
]}

Naoto Kajitani ^{[9
]}

Shuken Boku ^{[10
]}

Kazunari Ishii ^{[5
]}

Manabu Ikeda ^{[11
]}

Minoru Takebayashi ^{[5
]}

机构：

[1] Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka

[2] Department of Neuropsychiatry, Faculty of Medicine, Kindai University, Osaka

[3] Department of Psychiatry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima

[4] Department of Psychiatry, Arao Kokoronosato Hospital, Arao

[5] Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto

[6] Department of Geriatric Psychiatry, Mitsugumachi Clinic, Kumamoto

[7] Faculty of Social Welfare, Kumamoto Gakuen University, Kumamoto

[8] Department of Psychiatry, Kumamoto Seimei Hospital, Kumamoto

[9] Department of Frailty Research, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Aichi

[10] Department of Psychiatry, Mashiki Hospital, Kumamoto

[11] Center for Metabolic Regulation of Healthy Aging, Faculty of Life Sciences, Kumamoto University, Kumamoto

[12] Department of Radiology, Faculty of Medicine, Kindai University, Osaka

来源：

Fluids and Barriers of the CNS | / 21卷 / 1期

基金：

日本学术振兴会;

关键词：

Cerebrospinal fluid; Choroid plexus; Cognitive impairment;

D O I：

10.1186/s12987-024-00601-0

中图分类号：

学科分类号：

摘要：

Background: An increase in choroid plexus (CP) volume may be associated with cognitive decline in older individuals without dementia. In this study, we aimed to clarify whether CP volume can serve as an imaging marker of cognitive decline, determine how strongly CP volume is associated with cognitive decline, and explore factors associated with CP volume in older adults. Methods: We measured CP volume, brain parenchyma, and cerebrospinal fluid (CSF) spaces associated with disproportionately enlarged subarachnoid space hydrocephalus (DESH), an imaging feature of normal-pressure hydrocephalus, in community-dwelling older adults aged ≥ 65 years without dementia. Results: In 1,370 participants, lower Mini-Mental State Examination (MMSE) scores were significantly associated with higher CP volume, even after adjusting for DESH-related CSF space and brain parenchymal volume. CP volume was more strongly associated with MMSE scores than DESH-related CSF space and brain parenchymal volume. History of smoking, white matter hyperintensity, enlarged perivascular spaces, age, body mass index, and diabetes mellitus were also associated with increased CP volume. Conclusions: CP volume may be a highly sensitive imaging marker of cognitive decline in community-dwelling older adults without dementia, as it is linked to cognitive decline independently of brain parenchyma and CSF volumes. Our findings emphasize the importance of investigating CP volume increase to maintain cognitive function in older individuals. Accordingly, further longitudinal studies are required. © The Author(s) 2024.

引用

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