NLRP3 inflammasome in neuroinflammation and central nervous system diseases

被引：17

作者：

Xu, Wen ^{[1
]}

Huang, Yi ^{[2
]}

Zhou, Rongbin ^{[3
,4
]}

机构：

[1] Univ Sci & Technol China, Affiliated Hosp USTC 1, Neurol Dept, Div Life Sci & Med, Hefei 230001, Anhui, Peoples R China

[2] Hefei Comprehens Natl Sci Ctr, Inst Hlth & Med, Hefei 230601, Peoples R China

[3] Univ Sci & Technol China, Ctr Adv Interdisciplinary Sci & Biomed IHM, Sch Basic Med Sci, Div Life Sci & Med,Natl Key Lab Immune Response &, Hefei 230027, Anhui, Peoples R China

[4] Univ Sci & Technol China, Affiliated Hosp 1, Gerontol Inst Anhui Prov, Div Life Sci & Med,Dept Geriatr, Hefei 230001, Anhui, Peoples R China

来源：

CELLULAR & MOLECULAR IMMUNOLOGY | 2025年 / 22卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Neuroinflammation; NLRP3; inflammasome; Central nervous system (CNS) diseases; AMYLOID-BETA; GASDERMIN D; COGNITIVE IMPAIRMENT; PARKINSONS-DISEASE; MULTIPLE-SCLEROSIS; ALZHEIMERS-DISEASE; ISCHEMIC-STROKE; CELL-MIGRATION; NEURONAL DEATH; MESSENGER-RNA;

D O I：

10.1038/s41423-025-01275-w

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neuroinflammation plays an important role in the pathogenesis of various central nervous system (CNS) diseases. The NLRP3 inflammasome is an important intracellular multiprotein complex composed of the innate immune receptor NLRP3, the adaptor protein ASC, and the protease caspase-1. The activation of the NLRP3 inflammasome can induce pyroptosis and the release of the proinflammatory cytokines IL-1 beta and IL-18, thus playing a central role in immune and inflammatory responses. Recent studies have revealed that the NLRP3 inflammasome is activated in the brain to induce neuroinflammation, leading to further neuronal damage and functional impairment, and contributes to the pathological process of various neurological diseases, such as multiple sclerosis, Parkinson's disease, Alzheimer's disease, and stroke. In this review, we summarize the important role of the NLRP3 inflammasome in the pathogenesis of neuroinflammation and the pathological course of CNS diseases and discuss potential approaches to target the NLRP3 inflammasome for the treatment of CNS diseases.

引用

页码：341 / 355

页数：15

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