Harnessing the Power of Bacteriocins: A Comprehensive Review on Sources, Mechanisms, and Applications in Food Preservation and Safety

The Sustainable Development Goals (SDGs) emphasize the importance of food safety, prolonged shelf life, and reduced food waste, all of which rely on effective food preservation methods. Bacteriocins, natural antimicrobial substances produced by lactic acid bacteria (LAB), have potential applications in food preservation. This review highlights the role of LAB-derived bacteriocins in preserving food. Bacteriocins are highly effective against foodborne infections because they target cell membranes, break down enzymes, and interfere with cellular activities. The following study used molecular docking to understand the interaction of bacteriocins and their mode of action. With their natural origin and specific action, bacteriocins offer a promising strategy for preventing foodborne diseases and extending shelf life without impacting sensory characteristics. However, challenges such as stable manufacturing, regulatory hurdles, and cost effectiveness hinder the wide adoption of bacteriocins. Nevertheless, LAB-derived bacteriocins offer a safe and efficient approach to improving food preservation, enhancing food safety, and reducing reliance on artificial preservatives. Moreover, immobilized bacteriocins have the potential to be integrated into antimicrobial packaging films, providing a targeted way to reduce the risk of foodborne pathogen contamination and improve food safety. Exploring novel bacteriocins presents exciting opportunities for advancing food preservation and safety. The present study also highlights recent advancements in food preservation through bacteriocins.