Development of a Panel of Biomarkers for Differential Diagnosis of Multiple Sclerosis

被引：0

作者：

Ovchinnikova, L. A. ^{[1
]}

Dzhelad, S. S. ^{[1
]}

Simaniv, T. O. ^{[2
]}

Zakharova, M. N. ^{[2
]}

Lomakin, Y. A. ^{[1
]}

Gabibov, A. G. ^{[1
,3
]}

Illarioshkin, S. N. ^{[2
]}

机构：

[1] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow, Russia

[2] Res Ctr Neurol, Moscow, Russia

[3] Moscow State Univ, Moscow, Russia

来源：

DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2024年 / 519卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

multiple sclerosis; MS; autoantibodies; EBV; Epstein-Barr virus; demyelinating diseases;

D O I：

10.1134/S160767292460060X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Demyelinating diseases are a group of heterogeneous pathologies that affect the nervous system and reduce the quality of life. One of such diseases is multiple sclerosis (MS), an inflammatory autoimmune neurodegenerative disease of the central nervous system (CNS). At the initial stages, MS can mimic some infectious, neoplastic, genetic, metabolic, vascular, and other pathologies. Accurate differential diagnosis of this disease is important to improve the quality of life of patients and reduce possible irreversible damage to the central nervous system. In this work, we confirmed the possibility of using our previously proposed candidate panel of MS biomarkers to distinguish MS from neuromyelitis optica spectrum disorder (NMOSD) and amyotrophic lateral sclerosis (ALS). We have shown that our proposed panel (SPTAN1(601-644) + PRX451-494 + PTK6(301-344) + LMP1(285-330)) allows us to distinguish MS from ALS (AUC = 0.796) and NMOSD (AUC = 0.779).

引用

页码：593 / 596

页数：4

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