Molecular characterization of Streptococcus suis isolates recovered from diseased pigs in Europe

被引:6
作者
Li, Kevin [1 ,2 ]
Lacouture, Sonia [1 ,2 ]
Lewandowski, Eric [3 ]
Thibault, Eric [3 ]
Gantelet, Hubert [3 ]
Gottschalk, Marcelo [1 ,2 ]
Fittipaldi, Nahuel [1 ,2 ]
机构
[1] Univ Montreal, Fac Med Vet, Grp Rech Malad Infect Prod Anim, St Hyacinthe, PQ, Canada
[2] Univ Montreal, Fac Med Vet, Ctr Rech Infectiol Porcine & Avicole, St Hyacinthe, PQ, Canada
[3] Ceva Biovac, Beaucouze, France
基金
加拿大自然科学与工程研究理事会;
关键词
Swine infectious diseases; Streptococcus suis; genomic epidemiology; antimicrobial resistance; virulence-associated genes; Europe; ANTIBIOTIC-RESISTANCE; SWINE PATHOGEN; WILD BOARS; SEROTYPE; EPIDEMIOLOGY; MENINGITIS; INFECTION; VIRULENCE; DENMARK; SYSTEM;
D O I
10.1186/s13567-024-01366-y
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Streptococcus suis is a major swine pathogen and zoonotic agent, causing important economic losses to the porcine industry. Here, we used genomics approaches to characterize 251 S. suis isolates recovered from diseased pigs across Belgium, France, Germany, Hungary, the Netherlands, Spain, and the United Kingdom. We identified 13 serotypes, being serotypes 9 and 2 the most prevalent, and 34 sequence types (STs), including 16 novel STs, although ST16 and ST1 dominated the strain population. Phylogenetic analysis revealed complex genetic relationships, notable geographic clustering, and potential differential capacity for capsular switching among serotype 9 isolates. We found antimicrobial resistance (AMR) genes in 85.3% of the isolates, with high frequencies of genes conferring resistance to tetracyclines and macrolides. Specifically, 49.4% of the isolates harbored the tetO gene, and 64.9% possessed the ermB gene. Additionally, we observed a diverse array of virulence-associated genes (VAGs), including the classical VAGs mrp, epf, and sly, with variable presence across different genotypes. The high genetic diversity among European S. suis isolates highlights the importance of targeted antimicrobial use and flexible vaccine strategies. Rapid strain characterization is crucial for optimizing swine health management, enabling tailored interventions like the development of autovaccines to mitigate S. suis infections.
引用
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页数:16
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