Lacticaseibacillus rhamnosus G7 alleviates DSS-induced ulcerative colitis by regulating the intestinal microbiota

被引：1

作者：

Lao, Jianlong ^{[1
,2
]}

Chen, Man ^{[1
]}

Yan, Shuping ^{[1
]}

Gong, Han ^{[1
]}

Wen, Zhaohai ^{[1
]}

Yong, Yanhong ^{[1
]}

Jia, Dan ^{[1
,3
]}

Lv, Shuting ^{[1
]}

Zou, Wenli ^{[1
]}

Li, Junmei ^{[1
]}

Tan, Huiming ^{[1
]}

Yin, Hong ^{[3
]}

Kong, Xiangying ^{[4
]}

Liu, Zengyuan ^{[1
]}

Guo, Fucheng ^{[1
]}

Ju, Xianghong ^{[1
,2
]}

Li, Youquan ^{[1
,2
]}

机构：

[1] Guangdong Ocean Univ, Coll Coastal Agr Sci, Dept Vet Med, Zhanjiang 524088, Peoples R China

[2] Guangdong Ocean Univ, Shenzheng Inst, Marine Med Res & Dev Ctr, Shenzheng 518120, Peoples R China

[3] Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Anim Dis Control & Prevent, Lanzhou, Gansu, Peoples R China

[4] Haibei Integrated Serv Ctr Agr & Anim Husb, Haibei 810299, Qinghai, Peoples R China

来源：

BMC MICROBIOLOGY | 2025年 / 25卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Probiotics; Inflammatory; Lacticaseibacillus rhamnosus G7; Gut microbiota;

D O I：

10.1186/s12866-025-03904-w

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ulcerative colitis (UC) is an intestinal disease caused by many factors that seriously harms the health of humans and animals. Probiotics are currently widely used to treat intestinal inflammation; however, different strains are specific, and the functions and effects of different strains are still unclear. In this study, Lacticaseibacillus rhamnosus G7 isolated from herdsmen yogurt was used. The results of the in vitro evaluation revealed that it had good tolerance and safety. In mice with colitis, G7 alleviated weight loss and colon shortening and reduced the DAI score. After G7 treatment, the levels of proinflammatory factors (IL-1 beta, IL-6 and TNF-alpha) and histopathological scores decreased, whereas the level of IL-10 increased. In addition, G7 rebalanced the intestinal microbial composition of colitis model mice by increasing the abundance of Faecalibaculum and decreasing the abundance of Bacteroides and Escherichia_Shigella. In summary, G7 has great potential in the prevention of colitis. Not applicable.

引用

页数：14

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