Association of High-Sensitivity C-Reactive Protein (hs-CRP) with Weight Loss After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass at 10 Years: A Secondary Analysis of the SLEEVEPASS Randomized Clinical Trial

被引:0
作者
Saarinen, Ilmari [1 ,2 ]
Strandberg, Marjatta [3 ]
Hurme, Saija [1 ,3 ]
Gronroos, Sofia [1 ,2 ]
Juuti, Anne [4 ,5 ]
Helmio, Mika [1 ,3 ]
Salminen, Paulina [1 ,3 ]
机构
[1] Univ Turku, Turku, Finland
[2] Satasairaala Cent Hosp, Pori, Finland
[3] Turku Univ Hosp, Turku, Finland
[4] Helsinki Univ Hosp, Helsinki, Finland
[5] Univ Helsinki, Helsinki, Finland
关键词
Metabolic bariatric surgery; Sleeve gastrectomy; Roux-en-Y gastric bypass; Severe obesity; Chronic inflammation; High-sensitivity CRP; Hs-CRP; LIFE-STYLE INTERVENTION; CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS; BARIATRIC SURGERY; MEDICAL THERAPY; FOLLOW-UP; OBESITY; INFLAMMATION; RISK; CHOLESTEROL;
D O I
10.1007/s11695-024-07567-w
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background Severe obesity is associated with a low-grade chronic inflammation, and high-sensitivity C-reactive protein (hs-CRP) is a marker that can be used to evaluate chronic inflammation status. Metabolic bariatric surgery (MBS) is shown to decrease hs-CRP level, but long-term results are scarce, and association with weight loss outcomes is undetermined. This study aims to evaluate chronic inflammation in patients with obesity using hs-CRP, and its association with long-term weight loss outcomes after laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB). Methods The long-term follow-up data of SLEEVEPASS (ClinicalTrials.gov NCT00793143) randomized clinical trial (RCT) was used. Hs-CRP was measured at baseline, and at 6 months, 1, 3, 5, 7, and 10 years after surgery, and the association with weight and weight loss outcomes were analyzed. Results Hs-CRP at baseline was available for 59 out of 240 (24.6%) patients. In the whole study population, the nadir hs-CRP (mean estimate 1.14 mg/ml, 95% CI 0.87-1.49) was achieved at 3 years after surgery with a statistically significant difference to baseline (p = 0.003). No statistically significant difference was seen between LSG and LRYGB in hs-CRP change over time (operation*time interaction p = 0.540). Higher hs-CRP correlated with higher BMI at baseline (Spearman correlation 0.282, p = 0.030) and at 10 years (Spearman correlation 0.490, p = 0.001). At 10 years, a greater percentage total weight loss (%TWL) correlated with lower hs-CRP level (Spearman correlation - 0.558, p < 0.001). Baseline hs-CRP (Spearman correlation - 0.152, p = 0.299) and hs-CRP change in first 6 months postoperatively (Spearman correlation 0.167, p = 0.254) did not correlate statistically significantly with %TWL at 10 years. Conclusions MBS decreases hs-CRP also at long-term follow-up with weight loss as the driving force. Neither baseline hs-CRP nor hs-CRP change at 6 months were feasible as a predictive marker for long-term outcomes.
引用
收藏
页码:4378 / 4384
页数:7
相关论文
共 30 条
[1]   Weight and Metabolic Outcomes 12 Years after Gastric Bypass [J].
Adams, Ted D. ;
Davidson, Lance E. ;
Litwin, Sheldon E. ;
Kim, Jaewhan ;
Kolotkin, Ronette L. ;
Nanjee, M. Nazeem ;
Gutierrez, Jonathan M. ;
Frogley, Sara J. ;
Ibele, Anna R. ;
Brinton, Eliot A. ;
Hopkins, Paul N. ;
McKinlay, Rodrick ;
Simper, Steven C. ;
Hunt, Steven C. .
NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (12) :1143-1155
[2]   IFSO Worldwide Survey 2016: Primary, Endoluminal, and Revisional Procedures [J].
Angrisani, Luigi ;
Santonicola, A. ;
Iovino, P. ;
Vitiello, A. ;
Higa, K. ;
Himpens, J. ;
Buchwald, H. ;
Scopinaro, N. .
OBESITY SURGERY, 2018, 28 (12) :3783-3794
[3]  
Arnett DK, 2019, CIRCULATION, V140, pE596, DOI [10.1161/CIR.0000000000000678, 10.1016/j.jacc.2019.03.009, 10.1161/CIR.0000000000000677, 10.1016/j.jacc.2019.03.010]
[4]   Effect of Bariatric Surgery on Serum Inflammatory Factors of Obese Patients: a Systematic Review and Meta-Analysis [J].
Askarpour, Moein ;
Khani, Dana ;
Sheikhi, Ali ;
Ghaedi, Ehsan ;
Alizadeh, Shahab .
OBESITY SURGERY, 2019, 29 (08) :2631-2647
[5]   Three-Year Outcomes of Bariatric Surgery vs Lifestyle Intervention for Type 2 Diabetes Mellitus Treatment A Randomized Clinical Trial [J].
Courcoulas, Anita P. ;
Belle, Steven H. ;
Neiberg, Rebecca H. ;
Pierson, Sheila K. ;
Eagleton, Jessie K. ;
Kalarchian, Melissa A. ;
DeLany, James P. ;
Lang, Wei ;
Jakicic, John M. .
JAMA SURGERY, 2015, 150 (10) :931-940
[6]   Association of Serum hs-CRP Levels With the Presence of Obesity, Diabetes Mellitus, and Other Cardiovascular Risk Factors [J].
Ebrahimi, Mahmoud ;
Heidari-Bakavoli, Ali Reza ;
Shoeibi, Sara ;
Mirhafez, Seyed Reza ;
Moohebati, Mohsen ;
Esmaily, Habibollah ;
Ghazavi, Hamed ;
Karimian, Maryam Saberi ;
Parizadeh, Seyed Mohammad Reza ;
Mohammadi, Maryam ;
Ardabili, Hossein Mohaddes ;
Ferns, Gordon A. A. ;
Ghayour-Mobarhan, Majid .
JOURNAL OF CLINICAL LABORATORY ANALYSIS, 2016, 30 (05) :672-676
[7]   Obesity and inflammation: the linking mechanism and the complications [J].
Ellulu, Mohammed S. ;
Patimah, Ismail ;
Khaza'ai, Huzwah ;
Rahmat, Asmah ;
Abed, Yehia .
ARCHIVES OF MEDICAL SCIENCE, 2017, 13 (04) :851-863
[8]   DUAL CONTROL OF C-REACTIVE PROTEIN GENE-EXPRESSION BY INTERLEUKIN-1 AND INTERLEUKIN-6 [J].
GANTER, U ;
ARCONE, R ;
TONIATTI, C ;
MORRONE, G ;
CILIBERTO, G .
EMBO JOURNAL, 1989, 8 (12) :3773-3779
[9]   Change in C-reactive protein after Roux-en-Y gastric bypass through 7 years of follow-up [J].
Hinerman, Amanda S. ;
Barinas-Mitchell, Emma J. M. ;
Khoudary, Samar R. El ;
Courcoulas, Anita P. ;
Wahed, Abdus S. ;
King, Wendy C. .
SURGERY FOR OBESITY AND RELATED DISEASES, 2022, 18 (07) :902-910
[10]   ADIPOSE EXPRESSION OF TUMOR-NECROSIS-FACTOR-ALPHA - DIRECT ROLE IN OBESITY-LINKED INSULIN RESISTANCE [J].
HOTAMISLIGIL, GS ;
SHARGILL, NS ;
SPIEGELMAN, BM .
SCIENCE, 1993, 259 (5091) :87-91