Combined 25-hydroxyvitamin D concentrations and physical activity on mortality in US stroke survivors: findings from the NHANES

被引：2

作者：

Liao, Junqi ^{[1
,2
]}

Chen, Jingyi ^{[1
,2
]}

Wu, Huimin ^{[1
,2
]}

Zhu, Qing ^{[1
,2
]}

Tang, Xiaogang ^{[1
,2
]}

Li, Li ^{[1
,2
]}

Zhang, Aimei ^{[1
,2
]}

Mo, Peiyi ^{[1
,2
]}

Liu, Yan ^{[1
,2
]}

Yang, Xinyi ^{[1
,2
]}

Han, Yang ^{[3
]}

Chen, Zhaoyao ^{[1
,2
]}

Li, Wenlei ^{[1
,2
]}

Zhu, Yuan ^{[1
,2
]}

Wu, Minghua ^{[1
,2
,4
]}

机构：

[1] Nanjing Univ Chinese Med, Dept Neurol, Affiliated Hosp, 155 Hanzhong Rd, Nanjing 210029, Peoples R China

[2] Jiangsu Prov Hosp Chinese Med, Dept Neurol, Nanjing 210029, Peoples R China

[3] Nanjing Univ Chinese Med, Changshu Hosp, Dept Neurol, Suzhou, Jiangsu Provinc, Peoples R China

[4] Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Dept Neurol, Affiliated Hosp, 155 Hanzhong Rd, Nanjing 210029, Peoples R China

来源：

NUTRITION JOURNAL | 2025年 / 24卷 / 01期

基金：

中国国家自然科学基金;

关键词：

25-hydroxyvitamin D; Physical activity; Mortality; Stroke survivors; VITAMIN-D; ISCHEMIC-STROKE; SEDENTARY BEHAVIOR; SUPPLEMENTATION; GROWTH;

D O I：

10.1186/s12937-025-01076-x

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background25-hydroxyvitamin D [25(OH)D] concentrations and physical activity (PA) are linked and both are associated with changes in mortality. We examined the association of 25(OH)D and PA with all-cause or cause-specific mortality risk in stroke survivors.MethodsThe analysis included 677 stroke survivors from National Health and Nutrition Examination Survey (NHANES) 2007-2008 to 2017-2018. Independent and joint associations of 25(OH)D, PA and mortality among stroke survivors were analyzed using weighted Cox regression.ResultsWe identified 133 all-cause deaths [major adverse cardiovascular events (MACE), 34; non-MACE, 79] with a median follow-up of 5.8 years (interquartile, 2.8-8.9 years). In a range of adjusted models, high 25(OH)D was observed with lower all-cause mortality compared to low 25(OH)D (HR, 0.376; 95% CI, 0.233-0.607) and non-MACE (HR, 0.265; 95% CI, 0.143-0.490) mortality was consistently associated. At the same time, compared with no PA, PA was associated with a lower all-cause (HR, 0.280; 95%CI, 0.107-0.733) and non-MACE (HR, 0.266; 95%CI, 0.087-0.810) was associated with a lower risk of death. In addition, pooled analyses showed that stroke survivors with high 25(OH)D and PA had the lowest risk of all-cause death (HR, 0.132; 95%CI, 0.038-0.460) and non-MACE (HR, 0.092; 95%CI, 0.023-0.363), there is an additive interaction between 25(OH)D and PA in non-MACE.ConclusionIn conclusion, this study found that combining high 25(OH)D levels and PA showed an enhanced protective effect which demonstrated a synergistic effect between them in reducing mortality among stroke survivors. These findings provide new ideas and possibilities for the prevention and treatment of cardiovascular and cerebrovascular diseases, offering a reference for development of clinical practice guidelines in the future.

引用

页数：10

共 46 条

[31] Role of Vitamin D Deficiency in the Pathogenesis of Cardiovascular and Cerebrovascular Diseases [J].