Regulatory B cells in parasitic infections: roles and therapeutic potential

被引：0
作者：
Cai, Haojun [1 ]
Mu, Qianqian [1 ]
Xiong, Haiting [1 ]
Liu, Meichen [1 ]
Yang, Fengjiao [1 ]
Zhou, Ling [2 ]
Zhou, Biying [1 ]
机构：
[1] Zunyi Med Univ, Sch Basic Med, Zunyi, Peoples R China
[2] Zunyi Med Univ, Affiliated Hosp, Zunyi, Peoples R China
来源：
PARASITOLOGY RESEARCH | 2025年 / 124卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Parasitic infections; Regulatory B cells; Immunoregulation; Allergy; Inflammation; T-CELLS; HELMINTH INFECTION; HYGIENE HYPOTHESIS; ALLERGIC DISEASES; IMMUNE-RESPONSES; MICE; AUTOIMMUNE; INFLAMMATION; SUBSET; INTERLEUKIN-10;
D O I：
10.1007/s00436-024-08450-4
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Parasitic infection is a complex process involving interactions among various immune cells. Regulatory B cells (Breg cells), a subset of B lymphocytes with immunosuppressive functions, play a role in modulating immune responses during infection to prevent excessive immune activation. This article reviews the origin, phenotype, and immunoregulatory mechanisms of Breg cells. We summarize the immunomodulatory roles of Breg cells in various parasitic infections. We also discuss the potential applications of activating Breg cells through parasitic infections and their derived molecules in the treatment of certain allergic, autoimmune, and inflammatory diseases. The aim is to provide new perspectives for the future treatment of parasitic diseases and other related conditions.
引用
收藏
页数：15
相关论文
共 119 条
  • [1] Host protective roles of type 2 immunity: Parasite killing and tissue repair, flip sides of the same coin
    Allen, Judith E.
    Sutherland, Tara E.
    [J]. SEMINARS IN IMMUNOLOGY, 2014, 26 (04) : 329 - 340
  • [2] Leishmaniasis Worldwide and Global Estimates of Its Incidence
    Alvar, Jorge
    Velez, Ivan D.
    Bern, Caryn
    Herrero, Merce
    Desjeux, Philippe
    Cano, Jorge
    Jannin, Jean
    den Boer, Margriet
    [J]. PLOS ONE, 2012, 7 (05):
  • [3] Leishmania infantum Amastigotes Trigger a Subpopulation of Human B Cells with an Immunoregulatory Phenotype
    Andreani, Guadalupe
    Ouellet, Michel
    Menasria, Rym
    Gomez, Alejandro Martin
    Barat, Corinne
    Tremblay, Michel J.
    [J]. PLOS NEGLECTED TROPICAL DISEASES, 2015, 9 (02):
  • [4] Arai H., 2012, Biology of the Tapeworm Hymenolepis diminuta
  • [5] TIM-1 defines a human regulatory B cell population that is altered in frequency and function in systemic sclerosis patients
    Aravena, Octavio
    Ferrier, Ashley
    Menon, Madhvi
    Mauri, Claudia
    Aguillon, Juan Carlos
    Soto, Lilian
    Catalan, Diego
    [J]. ARTHRITIS RESEARCH & THERAPY, 2017, 19
  • [6] Arcanjo Angelica F, 2017, World J Biol Chem, V8, P151, DOI 10.4331/wjbc.v8.i2.151
  • [7] The hygiene hypothesis in autoimmunity: the role of pathogens and commensals
    Bach, Jean-Francois
    [J]. NATURE REVIEWS IMMUNOLOGY, 2018, 18 (02) : 105 - +
  • [8] Marginal Zone B Cells Regulate Antigen-Specific T Cell Responses during Infection
    Bankoti, Rashmi
    Gupta, Kshitiz
    Levchenko, Andre
    Staeger, Simona
    [J]. JOURNAL OF IMMUNOLOGY, 2012, 188 (08) : 3961 - 3971
  • [9] Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways
    Bhargava, Prerna
    Li, Changlin
    Stanya, Kristopher J.
    Jacobi, David
    Dai, Lingling
    Liu, Sihao
    Gangl, Matthew R.
    Harn, Donald A.
    Lee, Chih-Hao
    [J]. NATURE MEDICINE, 2012, 18 (11) : 1665 - +
  • [10] CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients
    Blair, Paul A.
    Norena, Lina Yassin
    Flores-Borja, Fabian
    Rawlings, David J.
    Isenberg, David A.
    Ehrenstein, Michael R.
    Mauri, Claudia
    [J]. IMMUNITY, 2010, 32 (01) : 129 - 140
12345678910