Hydrazide-Hydrazone Derivatives and Their Antitubercular Activity

被引：0

作者：

Thorat, B. R. ^{[1
]}

Mali, S. N. ^{[2
]}

Shah, Umang ^{[3
]}

Garg, A. ^{[4
]}

Agrawal, R. ^{[4
]}

Arvindekar, S. A. ^{[5
]}

Cruz, J. N. ^{[6
]}

de Oliveira, M. Santana ^{[7
]}

Shaik, A. B. ^{[8
,9
]}

Lokesh, B. V. S. ^{[10
]}

机构：

[1] Govt Coll Arts & Sci, Dept Chem, Aurangabad 431001, Maharashtra, India

[2] DY Patil Univ Deemed Univ, Sch Pharm, Sect 7, Navi Mumbai 400706, India

[3] Charotar Univ Sci & Technol, Ramanbhai Patel Coll Pharm, CHARUSAT Campus, Changa 388421, India

[4] Rajiv Acad Pharm, Dept Pharmaceut, Mathura 281001, Uttar Pradesh, India

[5] Bharati Vidyapeeth Coll Pharm, Dept Pharmaceut Chem, Kolhapur 416003, Maharashtra, India

[6] Univ Fed Amapa, Lab Modeling & Computat Chem, Dept Biol & Hlth Sci, BR-68902280 Macapa, AP, Brazil

[7] Museu Paraense Emilio Goeldi, Ave Magalhaes Barata, BR-66040170 Belem, PA, Brazil

[8] Vignans Fdn Sci Technol & Res, Sch Biotechnol & Pharmaceut Sci, Dept Pharmaceut Sci, Guntur 522213, Andhra Pradesh, India

[9] Saveetha Inst Med & Tech Sci, Saveetha Med Coll & Hosp, Ctr Global Hlth Res, Chennai 600077, India

[10] Univ Malaya, Fac Pharm, Dept Pharmaceut Chem, Kuala Lumpur 50603, Malaysia

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2025年 / 51卷 / 01期

关键词：

tuberculosis; hydrazide-hydrazones; Mycobacterium tuberculosis resistance; IN-VITRO; ANTIMYCOBACTERIAL ACTIVITY; 1,2,3-TRIAZOLE DERIVATIVES; DESIGN; AGENTS; ANTIBACTERIAL; PYRIDINE; HYBRIDS; SILICO; INDOLE;

D O I：

10.1134/S1068162025010054

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review aims to evaluate the mechanisms of action of current and emerging anti-TB drugs and molecules, emphasizing hydrazone functionality. Hydrazone compounds, featuring an azomethine group (R-1-HN-N=CR2R3), exhibit potent anti-TB and broad-spectrum anti-infective properties. It includes the synthesis and biological testing of hydrazide-hydrazones, with a focus on their anti-TB activities reported in the literature. It highlights promising candidates for future anti-TB therapies, underscoring hydrazones' role as a crucial pharmacophore in drug design against tuberculosis and other infectious diseases. This review summarizes pivotal findings in the development of hydrazone-based compounds, contributing to the ongoing search for effective anti-infective agents.

引用

页码：35 / 52

页数：18

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