Effect of Aspirin on Biomarkers of Barrett's Esophagus After Successful Eradication with Radiofrequency Ablation

被引：0

作者：

Bresalier, Robert S. ^{[1
]}

Shaheen, Nicholas J. ^{[2
]}

Hernandez, Mike ^{[3
]}

Buttar, Navtej ^{[4
]}

Marcon, Norman ^{[5
]}

Wani, Sachin ^{[6
]}

Muthusamy, Raman ^{[7
]}

Falk, Gary ^{[8
]}

Johnson, Tamara Tipps ^{[1
]}

Yan, Peiying ^{[9
]}

Huo, Xiaofang ^{[10
]}

Castille, Tawana A. ^{[11
]}

Della'Zanna, Gary ^{[12
]}

Richmond, Ellen ^{[12
]}

Jack Lee, J. ^{[3
]}

Brown, Powel ^{[11
]}

Souza, Rhonda ^{[13
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Gastroenterol Hepatol & Nutr, Houston, TX 77030 USA

[2] Univ North Carolina, Ctr Esophageal Dis & Swallowing, Chapel Hill, NC USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Biostat, 1515 Holcombe Blvd,Unit 1466, Houston, TX 77030 USA

[4] Mayo Clin, Dept Gastroenterol, Rochester, MN USA

[5] St Michaels Hosp, Dept Gastroenterol, Toronto, ON, Canada

[6] Univ Colorado, Dept Gastroenterol, Aurora, CO USA

[7] UNIV CALIF LOS ANGELES, Dept Gastroenterol, LOS ANGELES, CA USA

[8] Univ Penn, Dept Gastroenterol, Philadelphia, PA USA

[9] Univ Texas MD Anderson Canc Ctr, Dept Palliat Rehabil & Integrat Med, Houston, TX USA

[10] Univ Texas Southwestern Med Ctr Dallas, Dallas, TX USA

[11] Univ Texas, MD Anderson Canc Ctr, Houston, TX USA

[12] NCI, Div Canc Prevent, Rockville, MD USA

[13] Baylor Scott & White Res Inst, Ctr Esophageal Res, Dallas, TX USA

来源：

DIGESTIVE DISEASES AND SCIENCES | 2025年 / 70卷 / 03期

关键词：

Barrett's esophagus; Radiofrequency ablation; Chemoprevention; CDX2; Eicosanoids; INTESTINAL METAPLASIA; HAIR FOLLICLE; GROWTH; MUCOSA;

D O I：

10.1007/s10620-025-08908-0

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objectives/MethodsPlacebo-controlled phase II study evaluated aspirin's effect on CDX2 mRNA and prostanoid production in native and neosquamous epithelium after successful radiofrequency ablation (RFA) in Barrett's esophagus.ResultsAt 12 months TXB2, PGF2 alpha, PGD2, PGE2, PGE1, and alpha 13PGE2 increased in native squamous but not neosquamous epithelium in individuals randomized to placebo. Aspirin use significantly reduced CDX2 mRNA in native squamous epithelium, and was associated with decreases in PGE1, PGE2 and 13PGE2 in neosquamous epithelium.ConclusionsAfter RFA, native squamous and neosquamous epithelium exhibit different molecular markers and responses to aspirin suggesting that different sources of squamous progenitors contribute to esophageal re-epithelization.

引用

页码：1034 / 1042

页数：9

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