Antifungal activity of essential oils and their potential synergistic effect with amphotericin B

被引：1
作者：
Yuan, Xin [1 ]
Cao, Dan [1 ]
Xiang, Yanghui [1 ]
Jiang, Xiuzhi [1 ]
Liu, Jiaying [1 ]
Bi, Kefan [1 ]
Dong, Xu [1 ]
Wu, Tiantian [1 ]
Zhang, Ying [1 ,2 ]
机构：
[1] Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Dis, State Key Lab Diag & Treatment Infect Dis, Natl Clin Res Ctr Infect Dis,Affiliated Hosp 1,Sch, Hangzhou 310058, Peoples R China
[2] Jinan Microecol Biomed Shandong Lab, Jinan 250117, Peoples R China
来源：
SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期
关键词：
<italic>Candida albicans</italic>; Stationary phase; Essential oils; Antimicrobial activity; Drug combination; GC-MS; CANDIDA-ALBICANS; PLASTICITY;
D O I：
10.1038/s41598-024-82380-0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Candida albicans is a common opportunistic pathogen, causing infections ranging from superficial to bloodstream infections. The limited antifungal options and rising drug resistance challenge clinical treatment. We screened 98 essential oils and identified 48 with antifungal activity against Candida albicans at 1% concentration, determining their minimum inhibitory concentrations (MIC). Of these, 14 maintained fungicidal activity at lower concentrations (0.25% and 0.125%). 5 essential oils (Cinnamon, Satureja montana, Palmarosa, Lemon eucalyptus, and Honey myrtle) showed the highest inhibitory effects on stationary-phase Candida albicans and inhibited hyphae elongation. Synergistic effects were observed when combining Palmarosa with amphotericin B (AmB) against growing-phase Candida albicans, while Cinnamon and Satureja montana with AmB showed superior efficacy against stationary-phase infections. We identified the active components of 5 essential oils using gas chromatography-mass spectrometry (GC-MS) and found the following main constituents: Cinnamon primarily contains benzyl benzoate and eugenol, Satureja montana is dominated by carvacrol and cymene, Palmarosa features geraniol and geranyl acetate, Lemon eucalyptus includes dl-Isopulegol and citronellal, and Honey myrtle is characterized by citral and neral. Our results may aid in developing more effective antifungal treatments.
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页数：13
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