Protein lactylation in cancer: mechanisms and potential therapeutic implications

被引:0
作者
Rho, Hyunsoo [1 ,3 ]
Hay, Nissim [1 ,2 ]
机构
[1] Univ Illinois, Coll Med, Dept Biochem & Mol Genet, Chicago, IL 60607 USA
[2] Jesse Brown VA Med Ctr, Res & Dev Sect, Chicago, IL 60612 USA
[3] Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul, South Korea
基金
新加坡国家研究基金会;
关键词
METABOLIC-REGULATION; GENE-EXPRESSION; LACTATE;
D O I
10.1038/s12276-025-01410-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Increased glycolysis, which leads to high lactate production, is a common feature of cancer cells. Recent evidence suggests that lactate plays a role in the post-translational modification of histone and nonhistone proteins via lactylation. In contrast to genetic mutations, lactylation in cancer cells is reversible. Thus, reversing lactylation can be exploited as a pharmacological intervention for various cancers. Here we discuss recent advances in histone and nonhistone lactylation in cancer, including l-, d- and s-lactylation, as well as alanyl-tRNA synthetase as a novel lactyltransferase. We also discuss potential approaches for targeting lactylation as a therapeutic opportunity in cancer treatment.
引用
收藏
页码:545 / 553
页数:9
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