Clinical translation of photoacoustic imaging

被引:19
作者
Park, Jeongwoo [1 ,2 ,3 ]
Choi, Seongwook [2 ,4 ]
Knieling, Ferdinand [5 ]
Clingman, Bryan [6 ]
Bohndiek, Sarah [7 ,8 ]
Wang, Lihong V. [9 ,10 ]
Kim, Chulhong [1 ,2 ,3 ,11 ,12 ,13 ,14 ]
机构
[1] Pohang Univ Sci & Technol POSTECH, Dept Elect Engn, Pohang, South Korea
[2] POSTECH, Med Device Innovat Ctr, Daegu 41061, South Korea
[3] Kyungpook Natl Univ, Sch Convergence, Dept Biomed Convergence Sci & Technol, Daegu 41566, South Korea
[4] POSTECH, Inst Artificial Intelligence, Pohang, South Korea
[5] Friedrich Alexander Univ FAU Erlangen Nurnberg, Univ Hosp Erlangen, Dept Pediat & Adolescent Med, D-91054 Erlangen, Germany
[6] Seno Med Instruments Inc, San Antonio, TX USA
[7] Univ Cambridge, Dept Biochem, Cambridge, England
[8] Univ Cambridge, Canc Res UK Cambridge Inst, Cambridge, England
[9] Calif Inst Technol CALTECH, Andrew & Peggy Cherng Dept Med Engn, Pasadena, CA USA
[10] CALTECH, Dept Elect Engn, Pasadena, CA 91125 USA
[11] POSTECH, Dept Convergence IT Engn, Pohang, South Korea
[12] POSTECH, Dept Mech Engn, Pohang, South Korea
[13] POSTECH, Dept Med Sci & Engn, Pohang, Gyeongbuk, South Korea
[14] Opticho Inc, Pohang, South Korea
来源
NATURE REVIEWS BIOENGINEERING | 2025年 / 3卷 / 03期
基金
新加坡国家研究基金会; 英国工程与自然科学研究理事会;
关键词
MULTISPECTRAL OPTOACOUSTIC TOMOGRAPHY; MALIGNANT BREAST MASSES; HIGH-RESOLUTION; LYMPHATIC VESSELS; INDOCYANINE GREEN; LEARNING ANALYSIS; DISEASE SEVERITY; MOUSE-BRAIN; BLOOD-FLOW; ULTRASOUND;
D O I
10.1038/s44222-024-00240-y
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Photoacoustic imaging (PAI), also known as optoacoustic imaging, is a promising biomedical imaging technique that combines the benefits of rich optical contrast and high ultrasonic spatial resolution to overcome the limited penetration depth of light in living subjects. Basic biomedical research conducted with PAI in preclinical studies has generated much interest and shown outstanding potential for clinical and commercial translation. PAI has captured morphological, functional and molecular information in studies of living animals and humans, providing intrinsic clinical indicators from early diagnosis through to treatment monitoring. This Review presents the fundamentals of PAI technology and various clinical PAI systems and addresses key findings from pilot and clinical patient studies of human organ systems. The Review also discusses technical and non-technical challenges in clinical scenarios, emphasizes the importance of standardization in accelerating clinical translation, and summarizes the current state of the PAI regulatory process.
引用
收藏
页码:193 / 212
页数:20
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