A low-cost picowatt calorimeter using a flexible printed circuit board

被引：0

作者：

Zhu, Hanliang ^{[1
]}

Zhang, Yue ^{[1
]}

Wang, Lan ^{[1
]}

Brodsky, Jan ^{[2
]}

Gablech, Imrich ^{[2
]}

Feng, Jianguo ^{[3
]}

Yan, Qi-Long ^{[4
]}

Yang, Shujie ^{[5
,6
]}

Lee, Luke P. ^{[5
,6
,7
,8
,9
]}

Neuzil, Pavel ^{[1
]}

机构：

[1] Northwestern Polytech Univ, Sch Mech Engn, Key Lab Micro & Nano Syst Aerosp, Minist Educ, Xian 710072, Shaanxi, Peoples R China

[2] Brno Univ Technol, Fac Elect Engn & Commun, Dept Microelect, Brno 61600, Czech Republic

[3] Hefei Univ Technol, Sch Microelect, Hefei 230009, Anhui, Peoples R China

[4] Northwestern Polytech Univ, Sci & Technol Combust Internal Flow & Thermostruct, Xian 710072, Shaanxi, Peoples R China

[5] Harvard Univ, Harvard Med Sch, Cambridge, MA 02138 USA

[6] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[7] Univ Calif Berkeley, Dept Bioengn, Dept Elect Engn & Comp Sci, Berkeley, CA 94720 USA

[8] Sungkyunkwan Univ, Inst Quantum Biophys, Dept Biophys, Suwon, South Korea

[9] Ewha Womans Univ, Dept Chem & Nanosci, Seoul, South Korea

来源：

NATURE COMMUNICATIONS | 2025年 / 16卷 / 01期

基金：

中国国家自然科学基金;

关键词：

THERMAL PARAMETERS; DRIED DROPLETS; CHIP; PERFORMANCE; PATTERNS; DESIGN; GROWTH; FLOW;

D O I：

10.1038/s41467-025-58025-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Calorimetry is crucial in biology, chemistry, physics, and pharmaceutical research, enabling the detection of heat changes at nanowatt and picowatt levels. However, traditional calorimetry systems are often limited by high costs and complex fabrication processes. Here, we reduce the cost and fabrication complexity of microcalorimeters by utilizing widely available flexible printed circuit manufacturing processes. This device achieves temperature and power resolutions of approximate to 6 mu K and approximate to 654 pW in vacuum. Its feasibility is validated across a wide range of measurements, including salt crystallization, protein crystallization, and cellular metabolism. Our concept enhances the accessibility of microcalorimeters for high-resolution thermal analysis, which is challenging for conventional calorimeters.

引用

页数：13

共 66 条

[1] A Micromachined Picocalorimeter Sensor for Liquid Samples with Application to Chemical Reactions and Biochemistry [J].

Bae, Jinhye ;

Zheng, Juanjuan ;

Zhang, Haitao ;

Foster, Peter J. ;

Needleman, Daniel J. ;

Vlassak, Joost J. .

ADVANCED SCIENCE, 2021, 8 (05)

[2] The Nanolithography Toolbox [J].

Balram, Krishna C. ;

Westly, Daron A. ;

Davanco, Marcelo ;

Grutter, Karen E. ;

Li, Qing ;

Michels, Thomas ;

Ray, Christopher H. ;

Yu, Liya ;

Kasica, Richard J. ;

Wallin, Christopher B. ;

Gilbert, Ian J. ;

Bryce, Brian A. ;

Simelgor, Gregory ;

Topolancik, Juraj ;

Lobontiu, Nicolae ;

Liu, Yuxiang ;

Neuzil, Pavel ;

Svatos, Vojtech ;

Dill, Kristen A. ;

Bertrand, Neal A. ;

Metzler, Meredith G. ;

Lopez, Gerald ;

Czaplewski, David A. ;

Ocola, Leonidas ;

Srinivasan, Kartik A. ;

Stavis, Samuel M. ;

Aksyuk, Vladimir A. ;

Liddle, J. Alexander ;

Krylov, Slava ;

Ilic, B. Robert .

JOURNAL OF RESEARCH OF THE NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, 2016, 121 :464-475

[3]

Bastos M, 2023, NAT REV METHOD PRIME, V3, DOI 10.1038/s43586-023-00199-x

[4]

Calvet E., 2016, Recent progress in microcalorimetry

[5] Patterns in Dried Droplets to Detect Unfolded BSA [J].

Carreon, Yojana J. P. ;

Gomez-Lopez, Mary Luz ;

Diaz-Hernandez, Orlando ;

Vazquez-Vergara, Pamela ;

Moctezuma, Rosario E. ;

Saniger, Jose M. ;

Gonzalez-Gutierrez, Jorge .

SENSORS, 2022, 22 (03)

[6] Effects of substrate temperature on patterns produced by dried droplets of proteins [J].

Carreon, Yojana J. P. ;

Rios-Ramirez, Maricarmen ;

Vazquez-Vergara, Pamela ;

Salinas-Almaguer, Samuel ;

Cipriano-Urbano, I. ;

Briones-Aranda, Alfredo ;

Diaz-Hernandez, O. ;

Santos, Gerardo J. Escalera ;

Gonzalez-Gutierrez, Jorge .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2021, 203

[7] Patterns produced by dried droplets of protein binary mixtures suspended in water [J].

Carreon, Yojana J. P. ;

Gonzalez-Gutierrez, Jorge ;

Perez-Camacho, M. I. ;

Mercado-Uribe, Hilda .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2018, 161 :103-110

[8] Determination of dynamic contact angles within microfluidic devices [J].

Castro, Eric R. ;

Tarn, Mark D. ;

Ginterova, Pavlina ;

Zhu, Hanliang ;

Xu, Ying ;

Neuzil, Pavel .

MICROFLUIDICS AND NANOFLUIDICS, 2018, 22 (05)

[9] Heat conduction calorimeter for massively parallel high throughput measurements with picoliter sample volumes [J].

Chancellor, EB ;

Wikswo, JP ;

Baudenbacher, F ;

Radparvar, M ;

Osterman, D .

APPLIED PHYSICS LETTERS, 2004, 85 (12) :2408-2410

[10] Evaporation of Droplets on Superhydrophobic Surfaces: Surface Roughness and Small Droplet Size Effects [J].

Chen, Xuemei ;

Ma, Ruiyuan ;

Li, Jintao ;

Hao, Chonglei ;

Guo, Wei ;

Luk, B. L. ;

Li, Shuai Cheng ;

Yao, Shuhuai ;

Wang, Zuankai .

PHYSICAL REVIEW LETTERS, 2012, 109 (11)

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