Sex Differences in Metabolic Disorders of Aging and Obesity in People with HIV

被引：3

作者：

Alvarez, Jessica A. ^{[1
]}

Yang, Chin-An ^{[2
]}

Ojuri, Victoria ^{[3
]}

Buckley, Kahsavyah ^{[4
]}

Bedi, Brahmchetna ^{[3
]}

Musonge-Effoe, Joffi ^{[3
]}

Soibi-Harry, Adaiah ^{[3
]}

Lahiri, Cecile D. ^{[3
,5
]}

机构：

[1] Emory Univ, Dept Med, Div Endocrinol Metab & Lipids, Sch Med, Atlanta, GA USA

[2] Emory Univ, Laney Grad Sch, Atlanta, GA USA

[3] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA 30307 USA

[4] Emory Univ, Sch Med, Atlanta, GA USA

[5] 341 Ponce de Leon Ave NE Res Unit,Suite 5022, Atlanta, GA 30308 USA

来源：

CURRENT HIV/AIDS REPORTS | 2025年 / 22卷 / 01期

关键词：

Sex differences; HIV; Metabolic; Aging; Obesity; IMMUNODEFICIENCY-VIRUS-INFECTION; FATTY LIVER-DISEASE; ANTIRETROVIRAL THERAPY; OLDER-ADULTS; HEPATIC STEATOSIS; MUSCLE STRENGTH; RISK-FACTORS; WEIGHT-GAIN; SARCOPENIA; MEN;

D O I：

10.1007/s11904-024-00711-2

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Purpose of ReviewAs advances in antiretroviral therapy for people with HIV (PWH) have prolonged lifespans, prevalence of aging and obesity related metabolic disorders have increased. The purpose of this review is to summarize recent research assessing sex differences in metabolic disorders among PWH, including weight gain/obesity, steatotic liver disease, insulin resistance/diabetes, dyslipidemia, bone loss/osteoporosis, and sarcopenia.Recent FindingsA growing body of evidence shows that women with HIV are at increased risk of developing metabolic disorders compared to men, including body weight gain and obesity, type 2 diabetes mellitus, dyslipidemia, bone loss, and sarcopenia, while men with HIV are at higher risk for hepatosteatosis and hepatic fibrosis.SummaryFuture work should prioritize the adequate representation of women in HIV clinical studies. Understanding sex-specific mechanisms underlying metabolic dysfunction in PWH is imperative so that interventions can be developed to address a growing global epidemic of metabolic diseases.

引用

页数：23

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