Integrative spatial protein profiling with multi-omics

被引：2

作者：

Fan, Rong ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Yale Univ, Dept Biomed Engn, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06520 USA

[3] Yale Univ, Yale Canc Ctr, Sch Med, New Haven, CT 06520 USA

[4] Yale Univ, Yale Stem Cell Ctr, Sch Med, New Haven, CT 06520 USA

[5] Yale Univ, Yale Ctr Aging Biol Res Y Age, Sch Med, New Haven, CT 06520 USA

[6] Yale Univ, Sch Med, Human & Translat Immunol, New Haven, CT 06520 USA

来源：

NATURE METHODS | 2024年 / 21卷 / 12期

基金：

美国国家卫生研究院;

关键词：

RESOLUTION;

D O I：

10.1038/s41592-024-02533-x

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Spatial proteomics holds the potential to transform the study of proteins in situ in complex tissues, but it needs to be integrated with other layers of omics data to gain a holistic view of cellular function, heterogeneity and interactions, and the underlying mechanisms of these processes. I highlight current challenges and emerging opportunities for multi-omic spatial protein profiling to advance basic research and translational applications.

引用

页码：2223 / 2225

页数：3

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