Population genomics of Plasmodium ovale species in sub-Saharan Africa

被引：0

作者：

Carey-Ewend, Kelly ^{[1
]}

Popkin-Hall, Zachary R. ^{[2
]}

Simkin, Alfred ^{[3
,4
]}

Mueller, Meredith ^{[2
]}

Hennelly, Chris ^{[2
]}

He, Wenqiao ^{[2
]}

Moser, Kara A. ^{[2
]}

Gaither, Claudia ^{[2
]}

Niare, Karamoko ^{[3
,4
]}

Aghakanian, Farhang ^{[2
]}

Feleke, Sindew ^{[5
]}

Brhane, Bokretsion G. ^{[5
]}

Phanzu, Fernandine ^{[6
]}

Kashamuka, Melchior Mwandagalirwa ^{[7
]}

Aydemir, Ozkan ^{[8
]}

Sutherland, Colin J. ^{[9
]}

Ishengoma, Deus S. ^{[10
,11
]}

Ali, Innocent M. ^{[12
]}

Ngasala, Billy ^{[13
]}

Kalonji, Albert ^{[6
]}

Tshefu, Antoinette ^{[7
]}

Parr, Jonathan B. ^{[2
,14
,15
]}

Bailey, Jeffrey A. ^{[3
,4
]}

Juliano, Jonathan J. ^{[1
,2
,14
,15
]}

Lin, Jessica T. ^{[2
,14
,16
]}

机构：

[1] Univ North Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27514 USA

[2] Univ North Carolina, Inst Global Hlth & Infect Dis, Chapel Hill, NC USA

[3] Brown Univ, Dept Pathol, Providence, RI USA

[4] Brown Univ, Lab Med, Providence, RI USA

[5] Ethiopian Publ Hlth Inst, Addis Ababa, Ethiopia

[6] SANRU Asbl, Kinshasa, DEM REP CONGO

[7] Kinshasa Sch Publ Hlth, Kinshasa, DEM REP CONGO

[8] Univ Massachusetts, Chan Med Sch, Program Mol Med, Worcester, MA USA

[9] London Sch Hyg & Trop Med, London, England

[10] Natl Inst Med Res NIMR, Dar Es Salaam, Tanzania

[11] Kampala Int Univ Tanzania, Dept Biochem, Dar Es Salaam, Tanzania

[12] Univ Dschang, Fac Sci, Dept Biochem, Dschang, Cameroon

[13] Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania

[14] Univ North Carolina, Sch Med, Div Infect Dis, Chapel Hill, NC USA

[15] Univ North Carolina, Sch Med, Curriculum Genet & Mol Biol, Chapel Hill, NC USA

[16] Univ North Carolina, Sch Med, Dept Microbiol & Immunol, Chapel Hill, NC USA

来源：

NATURE COMMUNICATIONS | 2024年 / 15卷 / 01期

基金：

美国国家卫生研究院;

关键词：

SINGLE-NUCLEOTIDE POLYMORPHISMS; FALCIPARUM MALARIA; NATURAL-SELECTION; PARASITE; DIVERSITY; PROGRAM; PREVALENCE; UTILITIES; MUTATIONS; WALLIKERI;

D O I：

10.1038/s41467-024-54667-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Plasmodium ovale curtisi (Poc) and Plasmodium ovale wallikeri (Pow) are relapsing malaria parasites endemic to Africa and Asia that were previously thought to represent a single species. Amid increasing detection of ovale malaria in sub-Saharan Africa, we present a population genomic study of both species across the continent. We conducted whole-genome sequencing of 25 isolates from Central and East Africa and analyzed them alongside 20 previously published African genomes. Isolates are predominantly monoclonal (43/45), with their genetic similarity aligning with geography. Pow shows lower average nucleotide diversity (1.8x10(-4)) across the genome compared to Poc (3.0x10(-4)) (p < 0.0001). Signatures of selective sweeps involving the dihydrofolate reductase gene have been found in both species, as are signs of balancing selection at the merozoite surface protein 1 gene. Differences in the nucleotide diversity of Poc and Pow may reflect unique demographic history, even as similar selective forces facilitate their resilience to malaria control interventions.

引用

页数：13

共 95 条

[1] Plasmodium interspecies interactions during a period of increasing prevalence of Plasmodium ovale in symptomatic individuals seeking treatment: an observational study [J].

Akala, Hoseah M. ;

Watson, Oliver J. ;

Mitei, Kenneth K. ;

Juma, Dennis W. ;

Verity, Robert ;

Ingasia, Luicer A. ;

Opot, Benjamin H. ;

Okath, Raphael O. ;

Chemwor, Gladys C. ;

Juma, Jackline A. ;

Mwakio, Edwin W. ;

Brazeau, Nicholas ;

Cheruiyot, Agnes C. ;

Yeda, Redemptah A. ;

Maraka, Maureen N. ;

Okello, Charles O. ;

Kateete, David P. ;

Managbanag, Jim Ray ;

Andagalu, Ben ;

Ogutu, Bemhards R. ;

Kamau, Edwin .

LANCET MICROBE, 2021, 2 (04) :E141-E150

[2] Fast model-based estimation of ancestry in unrelated individuals [J].

Alexander, David H. ;

Novembre, John ;

Lange, Kenneth .

GENOME RESEARCH, 2009, 19 (09) :1655-1664

[3] Arboviruses as an unappreciated cause of non-malarial acute febrile illness in the Dschang Health District of western Cameroon [J].

Ali, Innocent M. ;

Tchuenkam, Valery P. K. ;

Colton, Mia ;

Stittleburg, Victoria ;

Mitchell, Cedar ;

Gaither, Claudia ;

Thwai, Kyaw ;

Espinoza, Daniel O. ;

Zhu, Yerun ;

Jamal, Haaris ;

Key, Autum ;

Juliano, Jonathan J. ;

Christopher, Tume B. ;

Piantadosi, Anne ;

Waggoner, Jesse J. ;

Collins, Matthew H. .

PLOS NEGLECTED TROPICAL DISEASES, 2022, 16 (10)

[4] Major subpopulations of Plasmodium falciparum in sub-Saharan Africa [J].

Amambua-Ngwa, Alfred ;

Amenga-Etego, Lucas ;

Kamau, Edwin ;

Amato, Roberto ;

Ghansah, Anita ;

Golassa, Lemu ;

Randrianarivelojosia, Milijaona ;

Ishengoma, Deus ;

Apinjoh, Tobias ;

Maiga-Ascofare, Oumou ;

Andagalu, Ben ;

Yavo, William ;

Bouyou-Akotet, Marielle ;

Kolapo, Oyebola ;

Mane, Karim ;

Worwui, Archibald ;

Jeffries, David ;

Simpson, Vikki ;

D'Alessandro, Umberto ;

Kwiatkowski, Dominic ;

Djimde, Abdoulaye A. .

SCIENCE, 2019, 365 (6455) :813-+

[5]

Amato R, 2017, LANCET INFECT DIS, V17, P164, DOI [10.1016/S1473-3099(16)30409-1, 10.1016/s1473-3099(16)30409-1]

[6] VEuPathDB: the eukaryotic pathogen, vector and host bioinformatics resource center [J].

Amos, Beatrice ;

Aurrecoechea, Cristina ;

Barba, Matthieu ;

Barreto, Ana ;

Basenko, Evelina Y. ;

Bazant, Wojciech ;

Belnap, Robert ;

Blevins, Ann S. ;

Bohme, Ulrike ;

Brestelli, John ;

Brunk, Brian P. ;

Caddick, Mark ;

Callan, Danielle ;

Campbell, Lahcen ;

Christensen, Mikkel B. ;

Christophides, George K. ;

Crouch, Kathryn ;

Davis, Kristina ;

DeBarry, Jeremy ;

Doherty, Ryan ;

Duan, Yikun ;

Dunn, Michael ;

Falke, Dave ;

Fisher, Steve ;

Flicek, Paul ;

Fox, Brett ;

Gajria, Bindu ;

Giraldo-Calderon, Gloria, I ;

Harb, Omar S. ;

Harper, Elizabeth ;

Hertz-Fowler, Christiane ;

Hickman, Mark J. ;

Howington, Connor ;

Hu, Sufen ;

Humphrey, Jay ;

Iodice, John ;

Jones, Andrew ;

Judkins, John ;

Kelly, Sarah A. ;

Kissinger, Jessica C. ;

Kwon, Dae Kun ;

Lamoureux, Kristopher ;

Lawson, Daniel ;

Li, Wei ;

Lies, Kallie ;

Lodha, Disha ;

Long, Jamie ;

MacCallum, Robert M. ;

Maslen, Gareth ;

McDowell, Mary Ann .

NUCLEIC ACIDS RESEARCH, 2022, 50 (D1) :D898-D911

[7] Genome-scale comparison of expanded gene families in Plasmodium ovale wallikeri and Plasmodium ovale curtisi with Plasmodium malariae and with other Plasmodium species [J].

Ansari, Hifzur Rahman ;

Templeton, Thomas J. ;

Subudhi, Amit Kumar ;

Ramaprasad, Abhinay ;

Tang, Jianxia ;

Lu, Feng ;

Naeem, Raeece ;

Hashish, Yasmeen ;

Oguike, Mary C. ;

Benavente, Ernest Diez ;

Clark, Taane G. ;

Sutherland, Colin J. ;

Barnwell, John W. ;

Culleton, Richard ;

Cao, Jun ;

Pain, Arnab .

INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2016, 46 (11) :685-696

[8] Discovery of GAMA, a Plasmodium falciparum Merozoite Micronemal Protein, as a Novel Blood-Stage Vaccine Candidate Antigen [J].

Arumugam, Thangavelu U. ;

Takeo, Satoru ;

Yamasaki, Tsutomu ;

Thonkukiatkul, Amporn ;

Miura, Kazutoyo ;

Otsuki, Hitoshi ;

Zhou, Hong ;

Long, Carole A. ;

Sattabongkot, Jetsumon ;

Thompson, Jennifer ;

Wilson, Danny W. ;

Beeson, James G. ;

Healer, Julie ;

Crabb, Brendan S. ;

Cowman, Alan F. ;

Torii, Motomi ;

Tsuboi, Takafumi .

INFECTION AND IMMUNITY, 2011, 79 (11) :4523-4532

[9] Microarray analyses reveal strain-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 variants following natural infection and vaccination [J].

Bailey, Jason A. ;

Berry, Andrea A. ;

Travassos, Mark A. ;

Ouattara, Amed ;

Boudova, Sarah ;

Dotsey, Emmanuel Y. ;

Pike, Andrew ;

Jacob, Christopher G. ;

Adams, Matthew ;

Tan, John C. ;

Bannen, Ryan M. ;

Patel, Jigar J. ;

Pablo, Jozelyn ;

Nakajima, Rie ;

Jasinskas, Algis ;

Dutta, Sheetij ;

Takala-Harrison, Shannon ;

Lyke, Kirsten E. ;

Laurens, Matthew B. ;

Niangaly, Amadou ;

Coulibaly, Drissa ;

Kouriba, Bourema ;

Doumbo, Ogobara K. ;

Thera, Mahamadou A. ;

Felgner, Philip L. ;

Plowe, Christopher, V .

SCIENTIFIC REPORTS, 2020, 10 (01)

[10] Tandem repeats finder: a program to analyze DNA sequences [J].

Benson, G .

NUCLEIC ACIDS RESEARCH, 1999, 27 (02) :573-580

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