Complexation of Baricitinib with β-Cyclodextrin and Its Dimeric Amino-Derivatives

被引：0

作者：

Garibyan, A. A. ^{[1
]}

Kurochkina, G. I. ^{[2
]}

Kutyasheva, N. V. ^{[2
]}

Grachev, M. K. ^{[2
]}

Terekhova, I. V. ^{[1
]}

机构：

[1] Russian Acad Sci, GA Krestov Inst Solut Chem, Ivanovo 153045, Russia

[2] Moscow Pedag State Univ, Moscow 119435, Russia

来源：

RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A | 2024年 / 98卷 / 14期

关键词：

baricitinib; cyclodextrins; dimeric derivatives; solubility; complex formation; BINDING; SOLUBILIZATION;

D O I：

10.1134/S0036024424703084

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A comparative study of the complexing and solubilizing capacity of beta-cyclodextrin and its new dimeric diaminocationic derivatives in relation to baricitinib, a new generation immunomodulator, is performed. Isothermal saturation is used to determine the solubility of baricitinib in the presence of the considered beta-cyclodextrins in a phosphate buffer solution (pH 6.8). Thermodynamic parameters of complex formation are calculated, and a binding mode is proposed on the basis of 1H NMR data. The effect of the structure of beta-cyclodextrin on the efficiency of complex formation and the solubilization of baricitinib is analyzed.

引用

页码：3497 / 3503

页数：7

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