Polycystic Ovary Syndrome and Sex Hormones in Bariatric Surgery Candidates

被引：0
作者：
Dong, Shiliang [1 ]
Law, Saikam [2 ]
Ou, Changrui [3 ]
Wu, Bian [4 ]
Dong, Zhiyong [1 ]
Yang, Wah [1 ]
Zhang, Xiaoguan [1 ,5 ]
机构：
[1] Jinan Univ, Affiliated Hosp 1, Dept Metab & Bariatr Surg, Guangzhou, Peoples R China
[2] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Gastrointestinal Surg, Guangzhou, Peoples R China
[3] Southern Med Univ, Sch Publ Hlth, Guangzhou, Peoples R China
[4] Kunming Univ Sci & Technol, Peoples Hosp Yunnan Prov 1, Dept Gen Surg, Affiliated Hosp, 157 Jingbi Rd, Kunming 650032, Yunnan, Peoples R China
[5] Dalang Hosp, Dept Gen Surg, Dongguan, Guangdong, Peoples R China
来源：
OBESITY SURGERY | 2025年 / 35卷 / 03期
关键词：
Polycystic ovary syndrome; Obesity; Sex hormones; BMI; Testosterone; INSULIN-RESISTANCE; SYNDROME PCOS; METABOLIC SYNDROME; PREVALENCE; OBESITY; WOMEN; OVERWEIGHT; CRITERIA; RATIO;
D O I：
10.1007/s11695-025-07740-9
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Background Polycystic ovary syndrome (PCOS) is a prevalent metabolic and endocrine disorder affecting women of reproductive age, particularly those with obesity. This syndrome is characterized by clinical/biochemical hyperandrogenism and/or ovulatory dysfunction, which can result in infertility. Purpose To investigate the prevalence of PCOS in candidates for bariatric surgery and to examine the correlation between PCOS and sex hormones in women with obesity. Methods A retrospective study analyzed 577 bariatric surgery candidates from 2015 to 2021 using RStudio. Normally distributed data were expressed as x +/- s and compared with ANOVA or T-test, while the Kruskal-Wallis test was used for non-normal data. Count data, presented as M [Q1, Q3], were analyzed with the Chi-square test. Logistic regression identified influencing factors, with P < 0.05 indicating statistical significance. Results The findings of our study reveal that the prevalence of PCOS among bariatric surgery candidates stands at 14.04%. Conversely, high-density lipoprotein cholesterol (HDL-C) levels tended to decrease with higher BMI categories (P = 0.02). Compared to the non-PCOS group, the PCOS group exhibits lower age and HDL-C levels. Still, they showed significantly elevated HOMA-IR, fasting blood glucose (FBG), luteinizing hormone (LH), total testosterone (TT), and luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio (P < 0.05). The logistic regression analysis of PCOS indicates that, compared to the control group, those with FBG levels exceeding 7 mmol/L (OR = 2.28, 95% CI 1.19 to 4.37, P = 0.01) and individuals with TT levels greater than 2.01 ng/ml (OR = 2.36, 95% CI 1.23 to 4.71, P = 0.01) exhibited an increased risk of PCOS. Conclusion PCOS is highly prevalent among female bariatric surgery candidates. It is significantly associated with younger age, lower HDL, higher FBG, and elevated TT levels. These factors may also serve as indicators for evaluating PCOS improvement and assessing surgical outcomes postoperatively.
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页码：984 / 991
页数：8
相关论文
共 62 条
  • [1] Jaacks L.M., Vandevijvere S., Pan A., Et al., The obesity transition: stages of the global epidemic, Lancet Diabetes Endocrinol, 7, pp. 231-240, (2019)
  • [2] Lizneva D., Suturina L., Walker W., Brakta S., Gavrilova-Jordan L., Azziz R., Criteria, prevalence, and phenotypes of polycystic ovary syndrome, Fertil Steril, 106, pp. 6-15, (2016)
  • [3] Teede H.J., Misso M.L., Costello M.F., Et al., Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome, Human Reprod (Oxford, England), 33, pp. 1602-1618, (2018)
  • [4] Li A., Zhang L., Jiang J., Et al., Follicular hyperandrogenism and insulin resistance in polycystic ovary syndrome patients with normal circulating testosterone levels, J Biomed Res, 32, pp. 208-214, (2017)
  • [5] Toosy S., Sodi R., Pappachan J.M., Lean polycystic ovary syndrome (PCOS): an evidence-based practical approach, J Diabetes Metab Disord, 17, pp. 277-285, (2018)
  • [6] Teede H.J., Tay C.T., Joham A.E., Polycystic ovary syndrome: an intrinsic risk factor for diabetes compounded by obesity, Fertil Steril, 115, pp. 1449-1450, (2021)
  • [7] Lim S.S., Davies M.J., Norman R.J., Moran L.J., Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis, Hum Reprod Update, 18, pp. 618-637, (2012)
  • [8] Li Y., Chen C., Ma Y., Et al., Multi-system reproductive metabolic disorder: significance for the pathogenesis and therapy of polycystic ovary syndrome (PCOS), Life Sci, 228, pp. 167-175, (2019)
  • [9] Baillargeon J.P., Nestler J.E., Commentary: polycystic ovary syndrome: a syndrome of ovarian hypersensitivity to insulin?, J Clin Endocrinol Metab, 91, pp. 22-24, (2006)
  • [10] Glueck C.J., Goldenberg N., Pranikoff J., Khan Z., Padda J., Wang P., Effects of metformin-diet intervention before and throughout pregnancy on obstetric and neonatal outcomes in patients with polycystic ovary syndrome, Curr Med Res Opin, 29, pp. 55-62, (2013)
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